The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

The impact of eight weeks of resistance training on some angiogenesis indicators in women with breast cancer

Document Type : Original Article

Authors
Fazlollah Fathollahi Shourabeh 1
Bahman Tarverdizadeh 2
Mozhgan Keihani 3
1 PhD student of Biochemistry and Exercise Metabolism, School of Humanities, Shahrekord University, Shahrekord, Iran.
2 Assistant professor, Department of Physical Education, School of Graduate Studies, Azad Islamic University of Bushehr Unit, Bushehr, Iran.
3 M.Sc. student in Physical Education and Sport Sciences, School of Graduate Studies, Azad Islamic University of Bushehr Unit, Bushehr, Iran.
10.22038/ijogi.2017.8868
Abstract
Introduction: Breast cancer is the most prevalent cancer in women. In Iran, %16 of all cancers in both male and female is related to breast cancer, and it has the first rank among Iranian women. Increasing levels of angiogenesis factors including NO, FGF, and VEGF is threatening in first stages of cancer, but it helps treatment and recovery in therapeutic level. Therefore this study was performed with aim to evaluate the impact of eight weeks of resistance training on some angiogenesis indicators in women with breast cancer.
Methods: This semi-experimental study was performed on 30 women with breast cancer who had undergone therapeutic level. They were randomly divided into two groups, control group (n=14) and resistance training group (n=16). The experimental group performed resistance training for 8 weeks, per week three sessions, with the intensity of 50-70 percent of 1RM. To study the variables of NO, FGF, and VEGF, 48 hours before and after the last session of training, the blood samples were taken of participants. Data were analyzed by SPSS software (version 19) and independent and dependent T test. P<0.05 was considered significant.
Results: The eight weeks of resistance training significantly increased the levels of VEGF, FGF and NO in experimental group than control group (P=0.0001).
Conclusion: The eight weeks of resistance training increased the level of some angiogenesis indicators and this increase in angiogenesis indicators leads to increased muscle mass and reduced fatigue in patients with breast cancer.
Keywords
Angiogenesis
Breast Cancer
Resistance training
  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63(1):11-30.
  2. Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 2002; 132(11 Suppl):3456S-64.
  3. Clemons M, Danson S, Howell A. Tamoxifen (‘Nolvadex’): a review: Antitumour treatment. Cancer Treat Rev 2002; 28(4):165-80.
  4. Farzanegi P, Habibian M, Delavari H. The effect of aerobic exercise on the levels of vascular endothelial growth factor and glucose in hypertensive postmenopausal women: a randomized clinical trial. Qom Univ Med Sci 2014; 8(4):6-12. (Persian).
  5. Semenza LG. Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling. J Cell Biochem 2007; 102(4):840–7.
  6. Pedersen BK. Exercise-induced myokines and their role in chronic diseases. Brain Behav Immun 2011; 25(2):811-6.
  7. Kamat A, Rajoria S, George A, Suriano R, Shanmugam A, Megwalu U, et al. Estrogen-mediated angiogenesis in thyroid tumor microenvironment is mediated through VEGF signaling pathways. Arch Otolaryngol Head Neck Surg 2011; 137(11):1146-53.
  8. Aghaalinejad H, Alizadeh S, Kazmi A, Minayi N, Shokrolahi F. The effect of endurance training on the level of tissue IL-6 and VEGF in mice with breast cancer. J Shahrekord Univ Med Sci 2014; 16(2):10-21. (Persian).
  9. Ghosh S, Ashcraft K. An IL-6 link between obesity and cancer. Frontiers Biosci 2012; 5(1):461-78.
  10. Langston W, Childow JH Jr, Booth BH, Barlow SC, Lefer DJ, Patel RP, et al. Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis. Free Radic Biol Med 2007; 42(5):720-9.
  11. Sasser AK, Sullivan NJ, Studebaker AW, Hendey LF, Axel AE, Hall BM. Interleukin-6 is a potent growth factor for ER-α-positive human breast cancer. FASEB J 2007; 21(13):3763-70.
  12. Schneider BP, Miller KD. Angiogenesis of breast cancer. J Clin Oncol 2005; 23(8):1782-90.
  13. Langsenlehner U, Krippl P, Renner W, Yazdani-Biuki B, Eder T, Köppel H, et al. Interleukin-10 promoter polymorphism is associated with decreased breast cancer risk. Breast Cancer Res Treat 2005; 90(2):113-5.
  14. Noorshahi M, Babaei A, Bigdeli MR, Ghasemi BM. The effect of six weeks of resistance training on tumor tissue VEGF and endostatin in mice with breast cancer. Sport Biosc 2013; 5(17):27-46. (Persian).
  15. Yang G, Nowsheen S, Aziz K, Georgakilas AG. Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs. Pharmacol Ther 2013; 139(3):392-404.
  16. Simon MP, Tournaire R, Pouyssegur J. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J Cell Physiol 2008; 217(3):809-18.
  17. Jing SW, Wang YD, Kuroda M, Su JW, Sun GG, Liu Q, et al. HIF-1α contributes to hypoxia-induced invasion and metastasis of metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression. Acta Med Okayama 2012; 66(5):399-407.
  18. Friedmann B, FreseF, Menold E, Bartsch P. Effects of acute moderate hypoxia on anaerobic capacity in endurance-trained runners. Eur J Appl Physiol 2007; 101(1):67-73.
  19. Pirouz M, Nourshahi M. The effect of eight weeks training in hypoxia-normobaric and normal situation on serum VEGF, erythropoietin concentration, fatigue index and VO2max. Quart J Sport Biosci Res 2013; 3(10):19-31. (Persian).
  20. Zielinski MR, Muenchow M, Wallig MA, Horn PL, Woods JA. Exercise delays allogeneic tumor growth and reduces intratumoral inflammation and vascularization. J Appl Physiol 2004; 96(6):2249-56.
  21. Shoorabeh FF, Dabidiroshan V, Saraf BS, Nuri R. Investigating the effects of regular resistance training and prostatic massage on proinflammatory markers and serum prostate-specific antigen levels in males with prostate cancer. Midd East J Rehabilit Health 2016; 3(1):e33651.
  22. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 2011; 11(9):607-15.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 20, Issue 3
June 2017
Pages 9-17