The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Evaluation OF Last Guidelines And Studies about The Best Treatment With Anticoagulant During Pregnancy in Woman with Mechanical Heart Valves

Document Type : Review Article

Authors
Ali Asghar Moeinipour 1
Alireza Sepehri Shamloo 2
Marzieh Lotfalizadeh 3
Jamil Esfahanizadeh 4
Behrouz Mottahedi 4
Hamid Hoseinikhah 1
1 Assistant professor, Department of Cardiovascular Surgery, Imam Reza (AS) Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Intern, Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Associate professor, Department of Obstetrics and Gynecology, Women's Health Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Associate professor, Department of Cardiovascular Surgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/ijogi.2015.4231
Abstract
Introduction: All women with prosthetic heart valve should undergo long-term treatment with anticoagulants drugs. Anticoagulants suitable for use in the treatment of pregnant women with prosthetic heart valves has met with controversy. Due to limited information on the strategies used in the treatment of pregnant women with prosthetic heart valve, this study was performed with aim to evaluate the advantages and disadvantages of the use of anticoagulants in pregnant women with prosthetic valve to achieve key points for medical use.
Methods: To access the performed studies about anticoagulant therapy in pregnant women with prosthetic valve, databases of PUBMED، MEDLINE، SCOPUS و EMBASE و DARE and also, related keywords were used. Last guidelines related to the coagulant therapy after surgery of prosthetic heart valve were studied.
Conclusion: best coagulation regimen in pregnant women with mechanical valve is using warfarin with dose <5 mg.   
Keywords
Heart mechanical valve
oral anticoagulant
pregnancy
Warfarin
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