Maternal and Fetal Outcomes of Vaginal Delivery or Repeat Cesarean in Mothers with Two Previous Cesarean Sections

Document Type : Original Article

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, Supporting the Family and the Youth of Population Research Core, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.

2 Gynecologist, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.

3 Gynecologist, Department of Obstetrics and Gynecology, Supporting the Family and the Youth of Population Research Core, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.

4 PhD Student in Biostatistics, Department of Epidemiology and Biostatistics, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Assistant Professor, Department of Obstetrics and Gynecology, Supporting the Family and the Youth of Population Research Core, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.

10.22038/ijogi.2025.87454.6420

Abstract

Introduction: Considering to the potential benefits of vaginal delivery (VD) for mothers and infants, and the attention of regulatory organizations to reduce the number of unnecessary cesareans, this study was conducted with aim to examine maternal and fetal complications of VD in individuals with a history of two previous cesareans (VBAC) and compare them with the repeat cesarean group.
Methods: This semi-experimental study was conducted in 2019 to 2021 on 100 pregnant women with a history of two previous cesareans visiting Imam Reza & Omolbanin Hospitals. Participants were referred to two groups: candidates for VBAC or cesarean delivery. Maternal and neonatal outcomes were compared in both groups. Data were analyzed using SPSS (version 24) and independent t, Chi-square, and Fisher tests. P<0.05 was considered significant.
Results: The mean number of pregnancies did not differ in the two groups (P>0.1). In the RCD group, the underlying diseases (diabetes, preeclampsia, and chronic hypertension) (P<0.001), blood transfusion and postpartum hemorrhage (P=0.009), admission to the NICU (12%) (P=0.001) were higher than the VBAC group. Satisfaction with delivery was significantly higher in VBAC group (96%) (P<0.001).
Conclusion: Given the increased complications after repeat cesarean, including postpartum hemorrhage rates, the need for blood transfusions, and lower maternal satisfaction with RCD, VBAC should be presented as a safe method for qualified mothers.

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  1. Talaulikar VS, Arulkumaran S. Vaginal birth after caesarean section. Obstetrics, Gynaecology & Reproductive Medicine 2015; 25(7):195-202.
  2. Bayrami R, Janghorban R. Beliefs of women with a history of Previous Cesarean Section regarding Vaginal Birth after Cesarean: A qualitative study. The Iranian Journal of Obstetrics, Gynecology and Infertility 2021; 24(6):90-101.
  3. Vaginal Birth After Cesarean Delivery (VBAC) 2024. https://www.acog.org/clinical/clinical-guidance/practice-bulletin/articles/2019/02/vaginal-birth-after-cesarean-delivery
  4. Sondgeroth KE, Wan L, Rampersad RM, Stout MJ, Macones GA, Cahill AG, et al. Risk of maternal morbidity with increasing number of cesareans. American journal of perinatology 2019; 36(04):346-51.
  5. Varlas VN, Rhazi Y, Bors RG, Penes O, Radavoi D. The urological complications of vaginal birth after cesarean (VBAC)–a literature review. Journal of Medicine and Life 2021;14(4):443.
  6. McMullan JC, Creswell L, Frazer M, McFetridge L, Mitchell H, Coyne C, et al. Trial of labour following two previous caesarean sections–A UK cohort study. European Journal of Obstetrics & Gynecology and Reproductive Biology 2024; 298:182-6.
  7. Denjean S, Reis D, Bräuer M, Längler A. Trial of labour after two caesarean sections (TOLA2C) and risk of uterine rupture, a retrospective single centre study. BMC Pregnancy and Childbirth 2024; 24(1):576.
  8. Horgan R, Hossain S, Fulginiti A, Patras A, Massaro R, Abuhamad AZ, et al. Trial of labor after two cesarean sections: A retrospective case–control study. Journal of Obstetrics and Gynaecology Research 2022; 48(10):2528-33.
  9. Kiwan R, Al Qahtani N. Outcome of vaginal birth after cesarean section: A retrospective comparative analysis of spontaneous versus induced labor in women with one previous cesarean section. Annals of African medicine 2018; 17(3):145-50.
  10. Tegegne GA, Rade BK, Yismaw AE, Taye W, Mengistie BA. Predictors of successful trial of labor after cesarean section (TOLAC) in women with one prior transverse cesarean section at Tertiary Hospitals in northwest Ethiopia: a multicenter study. BMC Pregnancy and Childbirth 2024; 24(1):240.
  11. Dy J, DeMeester S, Lipworth H, Barrett J. No. 382-trial of labour after caesarean. Journal of obstetrics and gynaecology Canada 2019; 41(7):992-1011.
  12. Li WH, Yang MJ, Wang PH, Juang CM, Chang YW, Wang HI, et al. Vaginal birth after cesarean section: 10 years of experience in a tertiary medical center in Taiwan. Taiwanese Journal of Obstetrics and Gynecology 2016; 55(3):394-8.
  13. Boatin AA, Cueto PD, Garba DL, Sawyer M, James K, Ngonzi J, et al. Trial of labour after caesarean section in Sub‐Saharan Africa: A systematic review and meta‐analysis. Reproductive, Female and Child Health 2024; 3(3):e104.
  14. Mirteymouri M, Ayati S, Pourali L, Mahmoodinia M, Mahmoodinia M. Evaluation of maternal-neonatal outcomes in vaginal birth after cesarean delivery referred to maternity of academic hospitals. Journal of family & reproductive health 2016; 10(4):206.
  15. Salehi M, Pourali L, Rahmani R, Vatanchi A, Fardi E, Mehrad-Majd H, et al. Vaginal Birth After Two Cesarean Sections (VBAC-2), Success Rate and Adverse Outcomes of VBAC-2 Versus VBAC-1 and Repeat Cesarean Sections: Systematic Review and Meta-Analysis. Journal of Obstetrics, Gynecology and Cancer Research 2024; 9(3):240-8.
  16. Pourali L, Vatanchi A, Ayati S, Mirteimouri M, Majd HM, Delkhah FA. The Success Rate and Pregnancy Outcomes in Trial of Labor after One or Two Cesarean Section: A Cross-Sectional Study. Journal of Midwifery & Reproductive Health 2024; 12(3).
  17. Atia O, Rotem R, Reichman O, Jaffe A, Grisaru-Granovsky S, Sela HY, et al. Number of prior vaginal deliveries and trial of labor after cesarean success. European Journal of Obstetrics & Gynecology and Reproductive Biology 2021; 256:189-93.
  18. Thapsamuthdechakorn A, Sekararithi R, Tongsong T. Factors associated with successful trial of labor after cesarean section: a retrospective cohort study. Journal of pregnancy 2018; 2018(1):6140982.
  19. Akter MJ, Shirin E. The outcome of Vaginal Birth after one caesarean section (VBAC). Journal of Bangladesh College of Physicians and Surgeons 2021; 39(1):36-45.
  20. Torri D Metz, MD,Vincenzo Berghella, MD, Vanessa A Barss, MD, Choosing the route of delivery after cesarean birth. www.uptodate.com © 2022 UpToDate, Inc. Dec 21, 2021.
  21. Emembolu JO. Vaginal delivery after two or more previous caesarean sections: is trial of labour contraindicated?. Journal of Obstetrics and Gynaecology 1998; 18(1):20-4.
  22. Tahseen S, Griffiths M. Vaginal birth after two caesarean sections (VBAC‐2)—a systematic review with meta‐analysis of success rate and adverse outcomes of VBAC‐2 versus VBAC‐1 and repeat (third) caesarean sections. BJOG: An International Journal of Obstetrics & Gynaecology 2010; 117(1):5-19.
  23. Doret M, Touzet S, Bourdy S, Gaucherand P. Vaginal birth after two previous c-sections: obstetricians–gynaecologists opinions and practice patterns. The Journal of Maternal-Fetal & Neonatal Medicine 2010; 23(12):1487-92.
  24. De Leo R, La Gamba DA, Manzoni P, De Lorenzi R, Torresan S, Franchi M, et al. Vaginal birth after two previous cesarean sections versus elective repeated cesarean: a retrospective study. American Journal of Perinatology 2020; 37(S 02):S84-8.
  25. Asadzadeh F, Mostafazadeh F, Rostamneghad M, Azemi F, Soltanii R. Comparison of Quality of Life in Women after Normal Vaginal Delivery and Cesarean Section. journal of health and care 2012; 14(4).
  26. Nazari S, Tabatabayee CM, Bagheri M, Sharifnia H. Prevalence and some maternal and neonatal outcomes of vaginal delivery after cesarean and repeat cesarean in a hospital repeated Bentolhoda Bojnoord. Journal of North Khorasan University of Medical Science 2016; 8(1):167-77.
  27. Dunn EA, O’Herlihy C. Comparison of maternal satisfaction following vaginal delivery after caesarean section and caesarean section after previous vaginal delivery. European Journal of Obstetrics & Gynecology and Reproductive Biology 2005; 121(1):56-60.
  28. Hadjigeorgiou E, Katsie C, Papadopoulou M, Christofi MD, Christoforou A. Women's experiences of VBAC in Cyprus: a qualitative study. BMC Pregnancy and Childbirth 2021; 21(1):766.
  29. Blomquist JL, Quiroz LH, MacMillan D, Mccullough A, Handa VL. Mothers' satisfaction with planned vaginal and planned cesarean birth. American journal of perinatology 2011; 28(05):383-8.