Recurrence and Survival Rate of Patients with Cervical Cancer in Shohada Tajrish Hospital during 10 years

Document Type : Original Article

Authors

1 Assistant Professor, Department of Obstetrics and Gynecology, Cancer Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Professor, Department of Infection, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Resident, Department of Ophthalmology, Student Research Committee, Cancer Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Professor, Department of General Surgery, Cancer Surgery Fellowship, Cancer Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Assistant Professor, Department of Obstetrics and Gynecology, Fellowship of Perinatology, Cancer Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

6 General Physician Student, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

10.22038/ijogi.2025.86263.6388

Abstract

Introduction: Cervical cancer is the seventh most common cancer worldwide and the sixth leading cause of death from malignancy in women. Given the lack of comprehensive studies in Iran on the recurrence and survival of this cancer, and the differences in the burden of the disease in different ethnic groups, this study was conducted with aim to investigate the recurrence and survival rates of patients with cervical cancer.
Methods: This cross-sectional descriptive-analytical study was conducted on 211 patients hospitalized at Shohada Tajrish Hospital during 2014 to 2024. Demographic data, tumor pathology (grade, type), HPV status, metastasis, tumor size, lymph node involvement, type of treatment, and recurrence and survival information were extracted from records and telephone calls. Survival analysis was performed using the Kaplan-Meier method and comparison of influential factors was performed using the Cox regression test. Data analysis was performed using SPSS software (version 26). P<0.05 was considered significant.
Results: The observed overall survival rates for one year, three years, and five years were 97.3, 85.3, and 57.6 percent, respectively. In the multivariate model analysis, advanced stage of disease (HR=0.209), metastasis (HR=0.25), and old age (HR=0.616) were the strongest predictors of decreased survival.
Conclusion: Old age, advanced pathological grade, disease recurrence, and metastasis are the factors that reduce survival in patients with cervical cancer. Early diagnosis in stages IA and IB and combined surgery-radiotherapy treatment have better outcomes. Increasing public awareness about regular screening, Pap smear and HPV test screening is essential to improve patient survival and early detection to reduce mortality from this cancer in high-risk populations.

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Main Subjects

References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 28, Issue 10
December 2025
Pages 24-35

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