The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

A Systematic Review of the Effects of Probiotics on the Outcomes of Assisted Reproductive Technologies: A Review Study

Document Type : Review Article

Authors
Bentolhosna Dehghan nayeri 1
Ghazaleh Eslamian 2
Aref Adeli Mosabbeb 1
Fatemeh Habibollahi 1
Kiana Hasibi 1
Sepehr Khoshbaf Khiabanian 1
Kimia Dehghan Sanej 1
1 M.Sc. Student of Food Sciences and Industry, Student Research Committee, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Assistant Professor, Department of Cellular and Molecular Nutrition, School of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
10.22038/ijogi.2025.87336.6410
Abstract
Introduction: Infertility is defined as the failure to conceive after 12 months of regular unprotected intercourse. The gut and vaginal microbiome play significant roles in fertility outcomes, influenced by various factors including nutritional components. Probiotics, as one such factors, may affect fertility outcomes either directly by modulating microbial growth or indirectly through effects on the immune system and metabolism. This study was conducted with aim to examine the impact of probiotics on the outcomes of assisted reproductive technology (ART).
Methods: In this systematic review, we searched Medline, Embase, Web of Science, Google Scholar, Science Direct, Scopus, Magiran, SID, ISC, and Cochrane Library databases without time restrictions up to March 2025 using the keywords: probiotics, infertility, assisted reproductive technologies, IVF, and IUI.
Results: Among the seven studies reviewed, the administration of vaginal probiotics did not have a significant impact on overall outcomes of ARTs. Additionally, probiotic-prebiotic combinations in women under 40 years old and those with recurrent implantation failures increased pregnancy rates and live birth. Specifically, vaginal probiotics reduced the incidence of miscarriage.
Conclusion: Althogh probiotics may be effective in certain aspects of fertility, the existing evidence is not definitive. The efficacy of probiotics is dependent on various factors, including the mode of administration, bacterial composition, and individual characteristics. Therefore, further studies with appropriate design are essential to determine the precise role of probiotics in reproductive medicine.
Keywords
Assisted Reproductive Technologies
Infertility
In Vitro Fertilization
Probiotics
Subjects
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 28, Issue 7
September 2025
Pages 77-92