Fetal and maternal complications of IVF pregnancies based on donated and non-donated oocytes: A single-center retrospective study

Document Type : Original Article

Authors

1 Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Resident, Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Faculty of Medicine, Shahid Beheshti University of Medical Sciences,Tehran, Iran.

10.22038/ijogi.2025.83595.6242

Abstract

Introduction: Various strategies have been used to treat infertile patients. These strategies include the use of in vitro fertilization (IVF) and other assisted reproductive cycles. The use of donor eggs is one of the strategies used for patients. The present study was conducted with aim to investigate the relationship between autologous and donor eggs with maternal and neonatal complications.
Methods: In this retrospective cohort study, the study population was all women with infertility who were eligible for in vitro fertilization and referred to Mahdieh State Hospital in Tehran during 2011-2021. In order to investigate maternal and neonatal complications in pregnancies resulting from in vitro fertilization using autologous or donated gametes, data related to maternal and neonatal complications variables were extracted using a checklist. Chi-square test or Fisher's exact test was used to compare qualitative variables. P<0.05 was considered significant.
Results: According to the results, the frequency of twins was lower in fresh eggs than in frozen eggs (p=0.01). Also, the frequency of preeclampsia, diabetes mellitus, hypertension, and placenta previa was lower in fresh eggs than in frozen eggs, but this difference was not statistically significant (p>0.05). The overall mean gestational age was higher in the donor egg group than in the other group, but this difference was not significant (p>0.05). The frequency of intrauterine growth restriction, large for gestational age, death, term, and tubal complications was higher in frozen eggs compared to fresh eggs, but no significant relationship was observed (p>0.05).
Conclusion: The frequency of twins was higher in patients who underwent non-donor eggs. In addition, maternal and neonatal complications were higher in patients who underwent non-donor and frozen eggs.

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References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 28, Issue 3
May 2025
Pages 1-9

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