The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

The relationship of estradiol level with clinical characteristics of postmenopausal women with endometrial malignancies and abnormal uterine bleeding

Document Type : Original Article

Authors
Tahereh Ashraf Ganjouei 1
Hadis Nasiri Shahandashti 2
1 Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
10.22038/ijogi.2024.79972.6092
Abstract
Introduction: Considering the relatively high importance and complications of endometrial malignancies, especially during menopause, and considering that the role of endocrine hormones was not fully clarified, this study was performed with aim to determine the relationship between estradiol levels and the clinical characteristics of postmenopausal women with bleeding and endometrial malignancy.
Methods: This analytical cross-sectional study was conducted in 2023 on 54 patients with postmenopausal bleeding suffering from endometrial malignancy who referred to Imam Hossein (AS) hospital. Demographic and clinical (signs and symptoms) characteristics and serum estradiol levels of patients were collected. Data were analyzed by SPSS software (version 23) and Man-Whitney and Chi-square tests. P<0.05 was considered significant.
Results: Serum estradiol level was 26.80±15.77 pg/ml. In addition, 37 people (68.5%) had normal levels and 17 (31.5%) had abnormal levels of estradiol. In the normal estradiol group compared to abnormal estradiol, the prevalence of endometrial thickness ≥ 4 mm (0.73% vs. 100% and p=0.018) and family history of uterine malignancy (35.2% vs. 83.8% and p=0.026) was less. The most common type of pathology in both groups was grade 1 endometrioid adenocarcinoma, and this difference was not significant (p=0.780).
Conclusion: There is a correlation between estradiol level with high endometrial thickness and family history of uterine malignancy in women with endometrial malignancy.
Keywords
Abnormal uterine bleeding
Endometrial malignancy
Estradiol
Menopause
Subjects
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 27, Issue 4
June 2024
Pages 9-17