The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

The effect of oral and injectable anticoagulant drugs on bleeding rate in patients undergoing gynecological oncological surgeries

Document Type : Original Article

Authors
Soheila Aminimoghaddam 1
Amineh Arab Khazael Mahabadi 2
1 Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2 Resident, Department of Obstetrics and Gynecology, Clinical Research Developmental Unit, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
10.22038/ijogi.2024.76397.5925
Abstract
Introduction: Women's cancers such as endometrium, ovary, cervix, and vulva are common and one of the most effective treatments is the use of surgical techniques. Today, the use of injectable anticoagulants (heparin and enoxaparin) before and after women's cancer surgeries is common in treatment protocols. The present study was performed with aim to compare the effect of oral (apixaban) and injectable (enoxaparin) anticoagulant drugs in patients undergoing gynecological oncological surgeries.
Methods: This clinical trial study was carried out from 2021 to 2022 on 80 women referred to the hospital of Iran University of Medical Sciences with the complication of women's cancer (ovary, uterus, cervix, vulva and vagina, etc.) whose disease was confirmed by diagnostic laboratory evaluations and specialist physician and were diagnosed for surgery. After discharge, all patients used two treatment protocols of oral anticoagulants or injectable drugs within 28 days. Demographic information and laboratory indices of patients were evaluated. Data analysis was done using SPSS statistical software (version 22) and Mann-Whitney test. P<0.05 was considered significant.
Results: There was no significant difference between the groups receiving oral and injectable anticoagulants in terms of bleeding time and hospitalization duration (p>0.05). Also, the amount of hemoglobin and platelets in both groups decreased after surgery compared to before surgery, which was statistically significant (p<0.05).
Conclusion: The use of oral and injectable anticoagulants has no effect on the amount of bleeding after surgery in patients with gynecological cancers.
Keywords
Apixaban
Heparin
Oncological surgeries
Subjects
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 26, Issue 12
February 2024
Pages 1-10