The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

A case report of mitotically active ovarian cellular fibroma with minor sex cord elements

Document Type : Case report

Authors
Amir Hossein Jafarian 1
Morteza Safari Tirtashi 2
Malihe Hasanzadeh Mofrad 3
1 Assistant professor, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Resident, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/ijogi.2023.22366
Abstract
Introduction: Mitotically active cellular fibroma (MACF) with Minor Sex Cord Elements is a extremely rare disease. Although imaging helps in the diagnosis to some extent, the final and definitive diagnosis is based on evaluation and histological studies. The main differential diagnosis of this tumor is ovarian fibrosarcoma, which has moderate to severe atypia and a poorer prognosis. In this study, a case of mitotically active ovarian cellular fibroma with minor sex cord elements is reported.
Case presentation: A 41-year-old woman referred to gynecologic clinic with abdominal pain and abnormal uterine bleeding in the form of spotting. Clinical findings had no signs for diagnosis. Serum Tumor markers including CA125 were within normal limit. Ultrasound and computed tomography (CT) were supportive of sex cord stromal tumors. After surgical procedures and pathologic evaluation, the patient was finally diagnosed as MACF with less than 10% sex cord elements.
Conclusion: Differentiating mitotically active cellular fibroma from fibrosarcoma which may have similar histological findings is important to prevent overtreatment of patient with cellular fibroma.
Keywords
Fibroma
Fibrosarcoma
Ovary
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 26, Issue 2
April 2023
Pages 119-123