The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

The Effect of Swimming Training on the Insulin Resistance and Expression of Adiponectin and APPL-1 Liver Genes Following Induced Polycystic Ovary Syndrome in Rats

Document Type : Original Article

Authors
Maryam Khalilinejad 1
Mandana Gholami 2
Fereshteh Shah Mohammadi Dermani 3
Farshad Ghazalian 2
1 PhD Student of Physical Education and Sports Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 Associate Professor, Department of Physical Education and Sports Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3 Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Islamic Azad University of Medical Sciences, Tehran, Iran.
10.22038/ijogi.2023.22160
Abstract
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women which is associated with insulin resistance (IR). Some Factors such as adiponectin and APPL-1 play a role in IR signaling that is affected by exercise. Therefore, the present study was conducted with aim to evaluate the effect of swimming training on the IR and the expression of adiponectin and APPL1 genes following induced PCOS in rats.
Methods: This experimental research was conducted in 2021 on 36 female wistar rats. The rats were divided in six groups. Swimming training was done (six and eight weeks/five days a week, 60 min each session/ flow of the water speed was increased from seven to 15 L/M). After 24hr of sacrifices the mice, the level of IR, expression of adiponectin and APPL1 genes were measured in the liver tissue. Data were analyzed using SPSS software (version 22) and two-way ANOVA. P< .05 was considered statistically significant.
Results: Six weeks of training had a significant effect on IR serum levels (P=0.001) and adiponectin gene expression (P=0.004), while it had no significant effect on APPL-1 gene expression (P=0.433). Also, eight weeks of exercises had a significant effect on the IR (P=0.001) and the expression of APPL-1 and adiponectin genes (P=0.001).
Conclusion: Swimming training can lead to significant changes in IR serum levels, expression of adiponectin and APPL-1 genes. It seems that 8 weeks if swimming training have positive effects in PCOS patients by improving the metabolic pathway.
Keywords
Adiponectin
APPL-1
Insulin Resistance
Polycystic Ovary Syndrome
Swimming
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 26, Issue 1
March 2023
Pages 40-53