The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

The relationship between vitamin D serum level and 2 year disease free survival of breast cancer

Document Type : Original Article

Authors
Fatemeh Homaee Shandiz 1
Sima Kadkhodayan 2
Faezeh Jafarian 3
Istak Rezaee 4
1 Associate Professor, Department of Radio-Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Assistant Professor, Department of Obstetrics and of Gynecology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnord, Iran.
4 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/ijogi.2019.13196
Abstract
Introduction: From past time, breast cancer has been one of clinical and common problems among women. Given that chronic vitamin D deficiency is prevalent among most Iranian women, this study was performed with aim to examine the relationship between vitamin D serum level and 2 year survival without incidents such as metastasis and death among patients with breast cancer. 
Methods: This cross-sectional retrospective study was performed on 360 patients with non-metastatic breast cancer in 2012-2017. Data collection tool was checklist. Serum levels of vitD were measured in early of breast cancer diagnosis before the start of non-surgical therapy (radio-oncology). The effects of vitD level on two year disease free survival was compared among patients with vitD deficiency and those with normal level of VitD. Data was analyzed by SPSS software (version 16) and Copplan and logRank tests and Chi-square test. PResults: 2year disease free survival was 91.3%. No significant difference was observed in 2year disease free survival between patients with vitD deficiency and those with normal level of VitD (p=0.313). However, survival time was higher in people with normal vitD serum levels, but this difference was not statistically significant (p>0.05).
Conclusion: Although the results of current study did not show significant relationship between the effect of vitD level and disease free survival, but the number of good prognosis was more in patients with normal serum levels than those with low levels that indicates the clinical value.
Keywords
Breast cancer
Disease free survival
Vitamin
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 22, Issue 2
April 2019
Pages 1-8