Effect of eight weeks intermittent exercise training on oxidative stress indices in women with preterm labor after coronary artery bypass graft surgery (CABG): randomized clinical trial

Document Type : Original Article

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

2 Assistant Professor, Department of Anesthesia, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Introduction: Oxidative stress is one of the indicators that changes during preterm labor as well as cardiovascular diseases; several factors are effective on this index. Therefore, this study was performed with aim to evaluate eight weeks of intermittent exercise training on oxidative stress indices in women with preterm labor after coronary artery bypass graft surgery (CABG).
Methods: This clinical randomized trial study was performed on 21 women with preterm delivery and a history of coronary artery graft surgery at Tabriz University of Medical Sciences in 2019. After random allocation, blood sample was taken from the samples and then the intervention group performed 24 sessions of intermittent exercise and the control group had her normal life. Serum levels of 8-hydroxy-2-dioxan-guanosine and urinary 8-hydroxy-2-deoxy-guanosine were measured before and after the intervention. Data were analyzed by SPSS software (version 19) and Shapirovilk, Independent t and t-student tests. P< 0.05 was considered statistically significant.
Results: The exercise program in the intervention group caused a significant difference compared to pre-exercise in serum (P=0.003) and urinary (P=0.003) concentrations of 8-Hydroxy-2-dioxychuanosine. Intergroup difference of the variables such as weight (P=0.048), body mass index (P=0.004), fat percentage (P=0.002), and serum 8-hydroxy-2-dioxane guanosine (P=0.001) and urinary (P=0.001) were observed between the intervention and control groups.
Conclusion: Intermittent exercise in women with a history of preterm labor undergoing coronary artery bypass graft surgery could cause changes in oxidative stress index.

Keywords

References

  1. Aghamohammadi D, Mehdinavaz Aghdam A, Khanbabayi Gol M. Prevalence of Infections Associated with Port and Predisposing Factors in Women with Common Cancers Under Chemotherapy Referred to Hospitals in Tabriz in 2015. Iran J Obstet Gynecol Infertil 2019; 21(11):7-13.
  2. Khanbabaei Gol M, Mobaraki-Asl N, Ghavami Z, Zharfi M, Mehdinavaz Aghdam A. Sexual Violence against Mastectomy Women Improved from Breast Cancer. Iran J Obstet Gynecol Infertil 2019; 22(5):52-60.
  3. Khanbabaei Gol M, Rezvani F, Ghavami Z, Mobaraki-Asl N. Prevalence of neuropathic pain and factors affecting sleep quality in women with breast cancer after radiotherapy. Iran J Obstet Gynecol Infertil 2019; 22(6):46-53.
  4. El-Hashimi D, Gorey KM. Yoga-specific enhancement of quality of life among women with breast cancer: Systematic review and exploratory meta-analysis of randomized controlled trials. J Evid Based Integr Med 2019; 24:2515690X19828325.
  5. Khanbabaei Gol M, Aghamohammadi D. Effect of intravenous infusion of magnesium sulfate on opioid use and hemodynamic status after hysterectomy: double-blind clinical trial. Iran J Obstet Gynecol Infertil 2019; 22(7):32-38.
  6. Montazer M, Hadadi Z, Ghavami Z, Khanbabaei Gol M. Relationship of Body Mass Index with Chronic Pain after Breast Surgery in Women with Breast Cancer. Iran J Obstet Gynecol Infertil 2019; 22(8):10-18.
  7. Strzyżewski KW, Pioruńska-Stolzmann M, Majewski W, Kasprzak M, Strzyżewski W. Effect of surgical treatment on lipid peroxidation parameters and antioxidant status in the serum of patients with peripheral arterial disease. Dis Markers 2013; 35(6):647-52.
  8. Engin KN, Yemişci B, Yiğit U, Ağaçhan A, Coşkun C. Variability of serum oxidative stress biomarkers relative to biochemical data and clinical parameters of glaucoma patients. Mol Vis 2010; 16:1260-71.
  9. Gutteridge JMC, Halliwell B. Mini-Review: Oxidative stress, redox stress or redox success? Biochem Biophys Res Commun 2018; 502(2):183-186.
  10. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114(12):1752-61.
  11. Cano Sanchez M, Lancel S, Boulanger E, Neviere R. Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: a systematic review. Antioxidants (Basel) 2018; 7(8). pii:E98.
  12. Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H, LLeonart ME. Oxidative stress and cancer: an overview. Ageing Res Rev 2013; 12(1):376-90.
  13. Bhardwaj JK, Mittal M, Saraf P, Kumari P. Pesticides induced oxidative stress and female infertility: a review. Toxin Reviews 2018: 1-13.
  14. Ferguson KK, McElrath TF, Chen YH, Loch-Caruso R, Mukherjee B, Meeker JD. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. Am J Obstet Gynecol 2015; 212(2):208.e1-8.
  15. Moore TA, Ahmad IM, Zimmerman MC. Oxidative stress and preterm birth: an integrative review. Biol Res Nurs 2018; 20(5):497-512.
  16. Sultana Z, Maiti K, Aitken J, Morris J, Dedman L, Smith R. Oxidative stress, placental ageing‐related pathologies and adverse pregnancy outcomes. Am J Reprod Immunol 2017; 77(5):e12653.
  17. Di Fiore JM, Vento M. Intermittent hypoxemia and oxidative stress in preterm infants. Respir Physiol Neurobiol 2019; 266:121-129.
  18. Young I, Woodside JV. Antioxidants in health and disease. J Clin Pathol 2001; 54(3):176-86.
  19. Maia A, Oliveira J, Lajnef M, Mallet L, Tamouza R, Leboyer M, et al. Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis. Acta Psychiatr Scand 2019; 139(5):420-33.
  20. Wu LL, Chiou CC, Chang PY, Wu JT. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta 2004; 339(1-2):1-9.
  21. Pinho RA, Araújo MC, Ghisi GL, Benetti M. Coronary heart disease, physical exercise and oxidative stress. Arq Bras Cardiol 2010; 94(4):549-55.  
  22. Nair SB, Iqbal K, Phadke MS, Jadhav UE, Khandekar J, Khandeparkar J. Is Beating Heart Coronary Artery Bypass Graft Surgery Associated with Lesser Oxidative Stress and Inflammatory Response? Research & Reviews: A Journal of Immunology 2019; 1(1-3):16-26.
  23. Samia BA, Youssef GA. Changes in urinary 8-hydroxydeoxyguanosine levels during heptathlon race in professional female athletes. J Hum Kinet 2014; 41(1):107-11.
  24. Nojima H, Watanabe H, Yamane K, Kitahara Y, Sekikawa K, Yamamoto H, et al. Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus. Metabolism 2008; 57(2):170-6.
  25. Friedenreich CM, Pialoux V, Wang Q, Shaw E, Brenner DR, Waltz X, et al. Effects of exercise on markers of oxidative stress: an Ancillary analysis of the Alberta Physical Activity and Breast Cancer Prevention Trial. BMJ Open Sport Exerc Med 2016; 2(1):e000171.
  26. Romano E Silva AC, Dias GM, de Carvalho JJ, De Lorenzo A, Kasal DAB. Research proposal: inflammation and oxidative stress in coronary artery bypass surgery graft: comparison between diabetic and non-diabetic patients. BMC Res Notes 2018; 11(1):635.
  27. Rodríguez-Pascual F, Busnadiego O, Lagares D, Lamas S. Role of endothelin in the cardiovascular system. Pharmacol Res 2011;63(6):463-72.
  28. Gramlich Y, Daiber A, Buschmann K, Oelze M, Vahl CF, Münzel T, et al. Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity. Oxid Med Cell Longev 2018; 2018:6598326.
  29. Alvandfar D, Alizadeh M, Khanbabayi Gol M. Prevalence of pregnancy varicose and its effective factors in women referred to gynecology hospitals in Tabriz. Iran J Obstet Gynecol Infertil 2019; 22(9):1-7.
  30. Fakhari S, Bile Jani I, Atashkhouei S, Khanbabayi Gol M, Soliemanzadeh S. Comparing the effect of hypotension treatment due to spinal anesthesia with ephedrine or phenylephrine on arterial blood gases and neonatal Apgar score during cesarean delivery in obese mothers: randomized clinical trial. Iran J Obstet Gynecol Infertil 2019; 22(10):12-20.
  31. Hejazi K, Ghahremani Moghaddam M, Darzabi T. Effects of an 8-Week Aerobic Exercise Program on Some Indicators of Oxidative Stress in Elderly Women. Iranian Journal of Ageing 2019; 13(4):506-517.
  32. Abdolmaleki Z, Saleh Sedghpour B, Bahram A, Abdolmaleki F. Validity and reliability of the physical self-description questionnaire among adolescent girls. Journal of Applied Psychology 2011; 4(4):42-55.
  33. Boomi Ghuchane Atigh M, Malekaneh M, Mashreghi Moghaddam HR, Anani Sarab G. Evaluation of oxidative stress and homocysteine level in patients with acute myocardial infarction: a case-control study. Journal of Birjand University of Medical Sciences 2016; 23(2):141-148.
  34. Kavitha S, Sridhar MG, Santhosh S. Oxidative Stress and Coronary Stenting. Innovative Journal of Medical and Health Science 2015; 5(4):146-149.
  35. Thomas GA, Cartmel B, Harrigan M, Fiellin M, Capozza S, Zhou Y, et al. The effect of exercise on body composition and bone mineral density in breast cancer survivors taking aromatase inhibitors. Obesity (Silver Spring) 2017; 25(2):346-351.
  36. Rock CL, Doyle C, Demark‐Wahnefried W, Meyerhardt J, Courneya KS, Schwartz AL, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin 2012; 62(4):243-74.
  37. Schwingshackl L, Dias S, Strasser B, Hoffmann G. Impact of different training modalities on anthropometric and metabolic characteristics in overweight/obese subjects: a systematic review and network meta-analysis. PloS One 2013; 8(12):e82853.
  38. Giangregorio L, McGill S, Wark JD, Laprade J, Heinonen A, Ashe MC, et al. Too Fit To Fracture: outcomes of a Delphi consensus process on physical activity and exercise recommendations for adults with osteoporosis with or without vertebral fractures. Osteoporos Int 2015; 26(3):891-910.
  39. Asuman AO, Ayşenur Y, Yaşar EH, Barış A, Mustafa E, Bilge K, et al. Paraoxonase Arylestarase and Oxıdatıve Stress in Coronary Artery Surgery Technıques with Desflurane Anesthesıa. Journal of Advances in Medicine and Medical Research 2017; 24(1):1-8.
  40. Rahimi R, Sharafi H. The effect of a bout of resistance exercise on 8-Hydroxy-2’-Deoxyguanosine in athletes and non-athletes. Knowledge and Health 2012; 7(1):1-7.
  41. Shin YA, Lee JH, Song W, Jun TW. Exercise training improves the antioxidant enzyme activity with no changes of telomere length. Mech Ageing Dev 2008; 129(5):254-60.
  42. Pourfazeli B, Azamian Jazi A, Faramarzi M, Mortazavi MJ. Effect of regular aerobic training on oxidative damage markers of lipids and proteins in rats exposed to radiation emitted by the Wi-Fi router. Journal of Torbat Heydariyeh University of Medical Sciences 2017; 5(2):11-19.
  43. Inayat M, Bany-Mohammed F, Valencia A, Tay C, Jacinto J, Aranda JV, et al. Antioxidants and biomarkers of oxidative stress in preterm infants with symptomatic patent ductus arteriosus. Am J Perinatol 2015; 32(9):895-904.

The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 23, Issue 3
May 2020
Pages 1-8

Files

Share

How to cite

Statistics