The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Comparison of the effect of nigella sativa and mefenamic acid on menstrual hemorrhage in the students with primary dysmenoreha

Document Type : Original Article

Authors
Farzaneh Jafarnejad 1
Fatemeh Mohanazadeh Falahieh 2
Hassan Rakhshandeh 3
Mohammad Taghi Shakeri 4
1 Instructor, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad , Iran.
2 M.Sc. of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
3 Assistant Professor, Department of Pharmacology, Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Professor, Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/ijogi.2016.6747
Abstract
Introduction: Nigella sativa is one of the plants traditionally used in the treatment of dysmenorrhea, but its effect on menstrual hemorrhage has not been reported. Therefore, this study was performed with aim to compare the effects of Nigella sativa and mefenamic acid on menstrual hemorrhage.
Methods:This double-blind clinical trial was performed on 70 students with primary dysmenorrhea who were resident dormitories of in Mashhad University of Medical Sciences in 2014. The patients were randomly assigned to two groups of mefenamic acid and Nigella sativa. The research was conducted in two stages. At first, all the students were followed for two cycles in terms of bleeding, and then each of the patients randomly received Nigella sativa or mefenamic acid capsules for two consecutive cycles. Data were analyzed using SPSS software (version 16), and independent t-test and Friedman test. P< 0.05 was considered significant.
Results: Mean bleeding before the intervention in nigella sativa group was 85.20 ±37.85 cc that increased to 85.62 ± 34.2 in the first and to 85.77 ± 31.81 in the second cycle of treatment. Mean bleeding before the intervention in mefenamic acid group was 83.77 ±38.31 and decreased to 78.05 ±32.66 in the first and to 76.85 ± 29.71 in the second cycle of treatment. Overall, two groups were not statistically significant in terms of bleeding in the first and second cycle of treatment (P<0.05).
Conclusion: Use of Nigella sativa can increase the amount of menstrual bleeding, but this increase was not significantly different with mefenamic acid.
Keywords
Mefenamic Acid
Menstrual bleeding
Nigella Sativa
Primary dysmenoreha
  1. Ryan KJ. Kistner's gynecology. 6th ed. NewYork: Mosby Incorporated; 1999. P. 342.
  2. Pernoll ML. Current obstetric & gynecologic diagnosis & treatment. Trans: Ghotbi R, Vaziri A, Nikravesh A, Soleimani M. Tehran: Tabib Pub; 2000. P. 158-62. (Persian).
  3. Drosdzol A, Skrypulec V. Dysmenorrhea in pediatric and adolescent gynecology. Ginekol Pol 2008; 7(7):499-503.
  4. Ziaei S, Zakeri M, Kazemnejad A. A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea. BJOG 2005; 112(4):466-9.
  5. Dmitrovic R, Peter B, Cvitkovic-Kuzmic A, Strelec M, Kereshi T. Severity of symptoms in primary dysmenorrhen--a Doppler study. Eur J Obstet Gynecol Reprod Biol 2003; 107(2):191-4.
  6. Mirzaee F, Bakhshi H, Yassini SM, Bashardust N. The prevalence and intensity of primary dysmenorrhea based on personality type in Rafsanjan high school students. J Rafsanjan Univ Med Sci 2003; 2(3):151-7.
  7. Novak E. Berek & novak gynecology .14th ed. New York: Lippincott Williams & Wilkins; 2007. P. 481-8.
  8. Muto MG. The vulva. In: Rayan KJ, Berkowitz RS, Barbieri RL, Dunaif AE, editors. Kistner's gynecology & women's health. 7th ed. St. Louis: Mosby; 1999. P. 58-80.
  9. Siboni SM, Spreafico M, Calo L, Maino A, Santagostino E, Federici AB, et al. Gynaecological and obstetrical problems in women with different bleeding disorders. Haemophilia 2009; 15(6):1291-9.
  10. Speroff L, Fritz M. Clinical gynecologic endocrinology and infertility. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. P. 539.
  11. Lethaby A, Augood C, Duckitt K, Farquhar C. Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding. Cochrane Database Syst Rev 2007; 17(4):CD000400.
  12. Safari H, Shahreza GR. Mefenamic acid and vitamin E on primary dysmenorrhea. J Army Univ Med Sci 2008; 4: 735-8.
  13. Zeraati F, Shobeiri F, Nazari M, Araghchian M, Bekhradi R. Comparative evaluation of the efficacy of herbal drugs (fennelin and vitagnus) and mefenamic acid in the treatment of primary dysmenorrhea. Iran J Nurs Midwifery Res 2014; 19(6):581-4.
  14. Karimian Z, Sadat Z, Bahrami N, Kafaie M. Comparison of chamomile and mefenamic acid capsules in hemorrhage of menstruation. Iran J Obstet Gynecol Infertil 2015; 18(157):11-7. (Persian).
  15. El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett 2006; 106(1):72-81.
  16. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, et al. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed 2013; 3(5):337-52.
  17. Majlisi MB. Bihar al-anwar. Beirut: Al-Wafa; 1983. P. 227.
  18. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res 2012; 26(8):1246-8.
  19. Ravindran J, Nair HB, Sung B, Prasad S, Tekmal RR, Aggarwal BB. Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential. Biochem Pharmacol 2010; 79(11):1640-7.
  20. Keyhanmanesh R, Bagban H, Nazemiyeh H, Mirzaei Bavil F, Alipour MR, Ahmady M. The relaxant effects of different methanolic fractions of nigella sativa on guinea pig tracheal chains. Iran J Basic Med Sci 2013; 16(2):123-8.
  21. Mirabi P, Dolatian M, Mojab F, Namdari M. Effect of valerian on bleeding and systemic manifestations of menstruation. J Med Plants 2012; 4(44):155-63. (Persian).
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 18, Issue 185
March 2016
Pages 10-15