Effect of resistance exercises with calcium consumption on level of anti-mullerian hormone and some metabolic indices in women with polycystic ovarian syndrome

Authors

1 Associate Professor, Department of Exercise Physiology, School of Humanities Sciences, Arak University, Arak, Iran.

2 M.Sc. in Exercise Physiology, Faculty School of Humanities Sciences, Arak University, Arak, Iran.

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinal disorders in women at reproductive age. In many cases, PCOS is associated with infertility and increased risk of metabolic syndrome. This study was performed with aim to investigate the effect of 8-week resistance exercise and calcium supplementation on anti-mullerian hormone (AMH) level and metabolic parameters in women with PCOS.
Methods: This semi-experimental study was performed with pretest–posttest design on 30 women with PCOS who were referred to one of the medical centers of Arak in 2014. They were randomly assigned to three groups of resistance exercise and placebo, resistance exercise and calcium supplementation consumption (1000 mg/d), and control with 10 cases in each group. The protocol consisted of 3 sessions per week of exercise for 8 weeks, each session including 1-2 sets of 5–20 repetitions at 40–60% of 1RM(one repetition maximum). Serum levels of AMH and metabolic parameters were assessed before and after the training period. Data were analyzed using SPSS software (version 18), and two-way ANOVA and ANCOVA tests.  PResults: After 8 week total cholesterol resistance exercise, LDL-c, triglycerides and insulin resistance index were significantly decreased (P<0.05). Data analysis showed that calcium supplementation in conjunction with resistance exercise leads to more improvement in metabolic indices and serum level of AMH (P<0.05).
Conclusion: Resistance training in conjunction with calcium supplementation for two months can have beneficial effects on metabolic indices and ovarian reserve in women with PCOS.

Keywords


  1. Vural B, Caliskan E, Turkoz E, Kilic T, Demirci A. Evaluation of metabolic syndrome frequency and premature carotid atherosclerosis in young women with polycystic ovary syndrome. Hum Reprod 2005; 20(9):2409–13.
  2. Gambineri A, Pelusi C, Manicardi E. Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors. Diabetes 2004; 53(9):2353–8.
  3. Cascella T, Palomba S, De Sio I, Manquso F, Giallauria F, De Simone B, et al. Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome. Hum Reprod 2008; 23(1):153-9.
  4. Larzadeh N, Ghasem Nejad A, Mohammad Pour J. Effect of metformin on outcome of intrauterine insemination (IUI) in insulin infertile women with polycystic ovarian syndrome. Iran J Obstet Gynecol Infertil 2014; 17(128):1-11. (Persian).
  5. Moran L, Norman RJ. Understanding and managing disturbances in insulin metabolism and body weight in women with polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol 2004; 18(5):719–36.
  6. Turan V, Sezer ED, Zeybek B, Sendag F. Infertility and the presence of insulin resistance are associated with increased oxidative stress in young, non-obese Turkish women with polycystic ovary syndrome.J Pediatr Adolesc Gynecol 2015; 28(2):119-23.
  7. Suresh S, Vijayakumar T. Correlations of insulin resistance and serum testosterone levels with lh:fsh ratio and oxidative stress in women with functional ovarian hyperandrogenism.Indian J Clin Biochem 2015; 30(3):345-50.
  8. Kushnir VA, Halevy N, Barad DH, Albertini DF, Gleicher N. Relative importance of AMH and androgens changes with aging among non-obese women with polycystic ovary syndrome.J Ovarian Res 2015; 8(1):45-9.
  9. Broer SL, Broekmans FJ, Laven JS, Fauser BC. Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications.Hum Reprod Update 2014; 20(5):688-701.
  10. Attarzadeh R, Sardar MA, Taghavi M, Ayaz Khosh Hava F. The effects of an aerobic exercise program on LH, FSH, TST and DHEA levels in obese women.Iran J Endocrinol Metab 2012; 14(1):39-46. (Persian).
  11. Conceição MS, Bonganha V, Vechin FC, Berton RP, Lixandrão ME, Nogueira FR, et al. Sixteen weeks of resistance training can decrease the risk of metabolic syndrome in healthy postmenopausal women.Clin Interv Aging 2013; 8:1221-8.
  12. Earnest CP, Johannsen NM, Swift DL, Gillison FB, Mikus CR, Lucia A, et al. Aerobic and strength training in concomitant metabolic syndrome and type 2 diabetes.Med Sci Sports Exerc 2014; 46(7):1293-301.
  13. Asemi Z, Foroozanfard F, Hashemi T, Bahmani F, Jamilian M, Esmaillzadeh A. Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome.Clin Nutr 2015; 34(4):586-92.
  14. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J, et al. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome.Gynecol Endocrinol 2012; 28(12):965-8.
  15. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association.Med Sci Sports Exerc 2007; 39(8):1423-34.
  16. Abazar E, Taghian F, Mardanian F, Forozandeh D. Effects of aerobic exercise on plasma lipoproteins in overweight and obese women with polycystic ovary syndrome.Adv Biomed Res 2015; 4:68-78.
  17. Harrison CL, Stepto NK, Hutchison SK, Teede HJ. The impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome. Clin Endocrinol 2012; 76(3):351-7.
  18. Saikumar P, Selvi VK, Prabhu K, Venkatesh P, Krishna P. Anti mullerian hormone: a potential marker for recruited non growing follicle of ovarian pool in women with polycystic ovarian syndrome.J Clin Diagn Res 2013; 7(9):1866-9.
  19. Moran LJ, Harrison CL, Hutchison SK, Stepto NK, Strauss BJ, Teede HJ. Exercise decreases anti-müllerian hormone in anovulatory overweight women with polycystic ovary syndrome: a pilot study.Horm Metab Res 2011; 43(13):977-9.
  20. Thomson RL, Buckley JD, Moran LJ, Noakes M, Clifton PM, Norman RJ, et al. The effect of weight loss on anti-Müllerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment.Hum Reprod 2009; 24(8):1976-81.
  21. Shi H, Dirienzo D, Zemel MB.Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB J 2001; 15(2):291-3.
  22. Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P.Hierarchy of the beta-cell signals controlling insulin secretion. Eur J Clin Invest 2003; 33(9):742-50.
  23. Williams PF, Caterson ID, Cooney GJ, Zilkens RR, Turtle JR.High affinity insulin binding and insulin receptor-effector coupling: modulation by Ca2+. Cell Calcium 1990; 11(8):547-56.
  24. Dumitrescu R, Mehedintu C, Briceag I, Purcărea VL, Hudita D. Metformin-clinical pharmacology in PCOs. J Med Life 2015; 8(2):187-92.
  25. Tehrani HG, Mostajeran F, Shahsavari S. The effect of calcium and vitamin D supplementation on menstrual cycle, body mass index and hyperandrogenism state of women with poly cystic ovarian syndrome. J Res Med Sci 2014; 19(9):875-80.
  26. Firouzabadi Rd, Aflatoonian A, Modarresi S, Sekhavat L, MohammadTaheri S. Therapeutic effects of calcium & vitamin D supplementation in women with PCOS.Complement Ther Clin Pract 2012; 18(2):85-8.
  27. Hossein Rashidi B, Haghollahi F, Tehranian N, Shariat M, Zayeri F, Bagheri M, et al. Therapeutic effects of vitamin D and calcium in patients with polycystic ovary syndrome. J Reprod Infertil 2006; 7(3):225-33