Comparison of the efficacy of Glyceryl trinitrate and Misoprostol on cervical ripening for curretage in pregnant women at first trimester

Document Type : Original Article


1 Assistant professor, Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

2 Resident, Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


Introduction: Cervical ripening is an essential technique for curettage in first trimester of pregnancy. In this regard, Prostaglandins such as Misoprostol or Dinoprostol are used.NO-releasing drugs are the other new ones. This study was performed with aim to compare the efficacy of NO-releasing drugs with Misoprostol as a known drug to determine the benefits and disadvantages of this method for cervical ripening in terms of surgical abortion.
Methods: This randomized, double-blind clinical trial was performed on 60 pregnant women admitted at department of gynecology of Shahid Akbarabadi hospital in 2014. In this study, 60 pregnant women (14 weeks of gestation) were divided into group A (primigravid, n=30) and group B (multipar, n=30). Furthermore, group A was divided into 2 subgroups of A1 (treated with Glyceryl trinitrate) and A2 (treated with vaginal Misoprostol), and group B was divided into 2 subgroups of B1 (treated with Glyceryl trinitrate) and B2 (treated with vaginal Misoprostol). The efficacy of two methods for cervical ripening in two subgroups of A and B was separately measured through the cervical dilatation at admission and 6 hours later.Data was analyzed using SPSS software (version 22) and Fisher Exact test and Chi-square. PResults: Based on the result of examination after using drugs, there was no significant difference between the efficacy of Misoprostol and Glyceryl trinitrate on cervical ripening in two main groups of studied patients (P>0.05).
Conclusion: Glyceryl trinitrate can be an appropriate substitute for Misoprostol on cervical ripening.

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