The Effect of Oral Isosorbide Dinitrate in Prevention of Severe Pre-eclampcia in Patients with Mild Pre-eclampcia

Document Type : Original Article

Authors

1 Associate Professor of Obstetrics and Gynecology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

2 Resident of Obstetrics and Gynecology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

3 Intern of Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Introduction: Preeclampsia is a specific syndrome in pregnancy, which the definite cause and treatment is still not known. Isosorbide dinitrate, a nitric oxide donor vasodilator drug, is proposed to be effective in decreasing high blood pressure in pregnant women with severe preeclampsia. In this study, effect of oral isosorbide dinitrate in preventing of develop mild preeclampsia to severe preeclampsia in pregnant women was evaluated.
Methods: In a randomized clinical trial all pregnant women with mild preeclampsia who were admitted in prenatal ward of Akbarabadi or Firoozgar hospital of Tehran during March 2007- June 2009, were investigated. Individuals were investigated as cases (treated with oral isosorbide dinitrate) and controls (without any drug therapy) and compared based on systolic and diastolic blood pressure and time of developing severe preeclampsia. Data was analyzed using SPSS software (version 16) by t-test Independent.
Results: The difference between the systolic and diastolic blood pressures at the beginning of the study and after 24 hours were respectively 20.22±8.94 and 9.11±3.10 mmHg in the case group and 3.55±6.14 and 1.11±6.40 mmHg in control group (p<0.001). The mean delay in developing severe preeclampsia in case and control groups were respectively 29.89±27.34 and 7.89±8.15 days (p<0.001).
 
Conclusion: Oral isosorbide dinitrate delays developing severe preeclampsia in patients with mild preeclampsia and is effective in the treatment of hypertension due to mild preeclampsia.

Keywords

References

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