Effect of Metoclopramide on Increased Milk Production in Mothers of Preterm Infants

Document Type : Original Article

Authors

1 Neonatologist, Neonatal Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Gynecologist, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Professor of Neonatology, Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Assistant professor of Neonatology, Neonatal Research Center, Mashhad University of medical sciences, Mashhad, Iran.

5 M.Sc. of Nursing, Neonatal Research Center, Mashhad University of medical sciences, Mashhad, Iran.

Abstract

Introduction: Human milk is the optimal primary nutritional source for premature infants. The strongest evidence of the benefit of human milk for premature infants is the reduced incidence of necrotizing enterocolitis. But one of the frequent problems that cause decreased milk production is mother’s stress. Therefore we decided to evaluate of metoclopramide effect on increase of milk production in mothers of preterm infants.
Methods: The randomized double- blinded case-control study enrolled women who planned to breastfeed and delivered in 28-34 weeks of gestation. They were randomized to receive 10mg of metoclopramide or placebo 3 times a day for 10 days starting within 48 hours of giving birth. Breast feeding education was standardized for all women. They recorded the volume of milk expressed at each pumping for 10 days.
Results: 60 women were enrolled and 49 women completed the study. 25 women received metoclopramide and 24 were included in placebo group. Two groups were similar in age, race, education, gestational age, and neonatal weight. There was no significant difference between milk volumes in the two groups in first days (P>0.16). But mean volume production in metoclopramide was significant higher than placebo group in the last 5 days of study (P<0.007).
Conclusion: Metoclopramide increases volume of breast milk in women with preterm infants.

Keywords

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