Comparison of Homocysteine of Serom in Pre-eclamtic with Normal Pregnancy

Document Type : Original Article



bjective: Comparing the changes of fasting homocysteine during the second and third trimesters in pre-eclamptic women with normal control group.
Methods: In a nested case control study within a cohort of 324 pregnant women with normal blood pressure in 20th gestational week, 20 pre-eclamptic women were selected. Having been matched for pregestational body mass index, age, gestational age at time clinical manifestation of preeclampsia, a control group of 40 were selected. Coming back to their serological data, the homocysteine levels of cases and controls during the second trimester (20th to 24th weeks) of pregnancy were compared. The comparisons were also carried out in third trimester when preeclampsia occurred.
Results: The fasting homocysteine levels were increased from 5.31 ± 1.4 μm/l to 7.54 ± 1.6 μm/l between second and third trimesters in preeclamptic group (P<0.01) and 4. 1 ± 1.3 μm/l to 5.2 ± 1.4 μm/l in control group (p<0.01).
Conclusion: The women who develop preeclampsia have higher homocysteine levels before clinical evidence of disease than women who remain normotensive during pregnancy. This data suggests endothelial dysfunction in preeclamptic women before clinical manifestation of preeclampsia.