Assessment of Effect of Glucose Tolerance in Pregnancy Outcome in Patients with Polycystic Ovarian Syndrome

Document Type : Original Article

Authors

1 Assistant professor of Obstetrics and Gynecology, Fatemeh Zahra Fertility & infertility Center, Babol University of MedicalSciences, Babol, Iran.

2 Medical Doctor, Babol University of Medical Sciences

3 Assistant professor of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

Introduction: pregnancy is associated with insulin resistance. Eighty percent of obese
and 30% of lean women with PCOS (poly cystic ovarian syndrome) demonstrate insulin
resistance before conception and as many as 30% are affected by impaired glucose tolerance
later in life. As there is paucity of data on the prevalence of carbohydrate impairment during
pregnancy and its effect on perinatal outcome and infant morbidity in PCOS patients, this
study was designed.
Materials and Methods: In this descriptive analytical study, pregnancy records of 40
PCOS patients were compared with 60 non PCOS patients randomly. All cases in the study
and the control group were screened for GDM (Gestational Diabetes Mellitus) with 50 gr
glucose challenge test (GCT) in initial weeks and 24-28 week of gestation. Patients with
glucose challenge test values of > 140 mg/dl were referred for the 3h /100gr oral glucose
tolerance test (GTT). The two groups were then compared for the complications of
pregnancy and delivery.
Results: BMI was significantly higher in patients in the study group than the control
group. Prevalence of GDM and impaired glucose tolerance (IGT) between the groups was
not statistically significance. Prevalence of preeclampcia was significantly higher in PCOS
patients than control ones. Prevalence of preterm labor, mode of delivery, mean birth
weight, proportion of babies admitted to NICU, placental abruption and placenta previa
were not statistically different between two groups.
Conclusion: We found no difference in GDM and IGT prevalence in two groups, but
prevalence of preeclampcia in patients with this syndrome was higher. 

Keywords

References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 9, Issue 2 - Serial Number 2
September 2007
Pages 97-103

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