The Comparison of Frequent Idiopathic Recurrent Abortions Frequency in Consanguineous and Non-Consanguineous Marriages

Document Type : Original Article

Authors

Abstract

Introduction: Spontaneous abortion is referred to the termination of pregnancy prior to
20 weeks of gestational age. Numerous factors have been described which associate
with recurrent wastage such as; uterine abnormalities, infections, immunological
factors, endocrinologic imbalance, chromosomal and genetic defects. It is accepted
that, if a balanced translocation is carried by one of the partners can cause repeated
spontaneous abortions as well as autosomal recessive; trait carrier can increase
homozygosity, which in turn, leads to an increased risk of abortion.
The purpose of this study is to determine the frequency of recurrent abortions in
consanguineous marriages in comparison to non-consanguineous marriages.
Material and Method: Cytogenetic evaluation of 354 couples with the history of
recurrent miscarriages was performed on the basis of G-banning technique. All other
possible etiologic factors were excluded. Then 177 couples were grouped in the
consanguineous marriage group and the remaining of 177 couples in nonconsanguineous
marriage group. Individual characteristics were collected in a
questionnaire and analyzed by descriptive statistical chi-Square and Fisher test.
Results: The prevalence of state of balanced translocation was found in only 26
partners (7.34%). Among them, 12 individuals (3.38%) appeared in consanguineous
group and the remaining 14 partners (3.95%) were seen in non-consanguineous group.
The frequency of abortions was significantly more common in women with 2
spontaneous abortions whereas the fewer incidences appeared in women with 10
recurrent miscarriages. On the other hand the numbers of abortions beyond the 3 cases
were more prominent in consanguineous group in contrast to the non-consanguineous
group.
Conclusion: In consanguineous marriages in which recurrent miscarriages are
occurring, In the case of normal karyotype, an autosomal recessive disorder could be
postulated. 

Keywords

References

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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 9, Issue 2 - Serial Number 2
September 2007
Pages 23-31

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