Accuracy of Frozen Section in Diagnosis of Ovarian Mass in Isfahan Medical Hospital 2005

Document Type : Original Article



Introduction: Malignant ovarian tumor is one of the most fatal gynaecologic
malignancies. Of all the gynecologic cancers, ovarian malignancies represent the
greatest clinical challenges. It has the highest fatality to case ratio of all the gynecologic
To provide optimal management of a patient with an adnexal mass, it is important to
differentiate between malignant and benign pathology prior to and during surgery. Preoperative
discrimination between the malignant and benign adnexal mass can be made
with patient characteristics such as age, menopausal status, sonography and CA125
level in the peripheral blood.
Frozen section has long been used as a diagnostic tool for intraoperative histopathologic
determination of various surgical conditions and has an acceptable accuracy for clinical
use, including gynecological diseases.
The accuracy of the technique has been reported. The aim of the present study was to
examine the accuracy of frozen section diagnosis of adnexal mass in Isfahan
Materials and Methods: This is a descriptive study done in Isfahan in 2005. A total
of 45 surgically removed ovarian tumors were studied. Each ovarian tumor sample was
evaluated for histopathologic diagnosis using both Frozen section and paraffin seethes.
Interpretation was separate and blinded to benign and malignant in each technique.
Results: From 45 patients of whom 68.8% had a benign tumor, 31.2% had a malignant
tumor at definitive histological assessment. Sensitivity of frozen section for benign and
malignant tumors was 100% and 88.5% respectively. Specificity of frozen section for
benign tumors was 88.5%, and for malignant tumors 77%.
Conclusion: Frozen section appears to be an accurate technique for the
histopathologic diagnosis of ovarian tumors. 


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