Three Therapeutic Methods for Polycystic Ovarian Syndrome

Document Type : Original Article


1 Associat Professor of Gynecology, Women Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant Professor of Gynecology, Women Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Resident of of Gynecology, Women Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4 Assistant Professor of Biostatics, Mashhad University of Medical Sciences, Mashhad, Iran


Introduction: About 10-15% of women in the reproductive ages suffer from infertility. The most common cause of infertility with female factor is ovulation disorders (35-40%) and among them polycystic ovary syndrome (PCOS) is the most common. These patients suffer from insulin resistance, obesity and increase in androgens; many recent studies have focused on the effects of insulin sensitizing agents like metformine on the patients with PCOS. The aim of this study was to evaluate the efficacy of the three therapeutic methods of clomiphen citrate (CC), metformine and clomiphen citrate plus metformine on infertile women with PCOS.
Materials and Methods: This clinical trial study performed in the year 2004 at Montaserie Hospital of Mashhad University of Medical Sciences, on three groups of 20 PCOS Patients. This study was approved by the local committee of medical ethics. The women in the first group were treated with clomiphen citrate, the second group with metformine and the third group with clomiphen plus metformine for 3 months. Data were analyzed by SPSS software, by using t-student and c2. p£0.05 was statistically significant.
Results:Over all twenty nine (48.3%) of women conceived, with the highest rate (%70) belonging to the group treated with clomiphen citrate plus metformine (group three). There was a significant difference comparing to the other two groups (p=0.028). This finding was even more significant in the cases with high levels of serum testosterone and hirsutism.
Conclusion: Combination of metfomine plus clomiphen citrate significantly improves ovulation and pregnancy rates in patients with PCOS.


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