Evaluation the Relationship between Helicobacter Pylori Infection and Vomiting During Pregnancy

Document Type : Original Article


1 Associate Professor of Obstetrics & Gynecology, Semnan University of Medical Sciences, Semnan, Iran

2 Associate Professor of Public Health & Epidemiology, Semnan University of Medical Sciences, Semnan, Iran

3 Associate Professor of Internal Diseases, Semnan University of Medical Sciences, Semnan, Iran


Introduction: Nausea and vomiting in early stages of pregnancy is a common complaint. Hyperemesis gravidarum is the most severe form of this condition that happens in 1% to 2% of all pregnancies. Recently Helicobacter pylori infection has been mentioned in the etiology of vomiting in pregnancy. Having considered that treatment of H pylori infection with antibiotics is possible; it can be a step toward the treatment of these patients. This study was carried out to find the correlation between nausea and vomiting in pregnancy and H pylori infection.
Materials and Method: This cross sectional study was performed on 100 hospitalized pregnant women (who had over three episodes of vomiting within 24 hours) and 100 outpatients (who had less than three episodes of vomiting within 24 hours or had not any vomiting). This study was carried out at Amir–al–momenin hospital from April 2004 to January 2005.
Three cc bloods were taken from each patient and anti H pylori antibody was checked by ELISA method. Serum levels above 20 IU/ml were considered to be positive. The analyses of the data were carried out by using Chi- square and Mann-Whitiny tests.
Results: Fifty seven percent of hospitalized patients and 39% of outpatients were contaminated with H pylori, which showed a statistically significant difference (OR=2/70, 95%, CI:1/41-3/80, p=0/011).
Conclusion: There is a correlation between H pyloi infection and three or more episodes of nausea and vomiting in 24 hours from the 6th to 16th weeks of pregnancy.


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