Association of Fetal Gender with Maternal Serum β-hCG and Testosterone in Normotensive and Preeclamptic Pregnancies

Document Type : Original Article

Authors

1 Assistant Professor of Obstetrics & Gynecology, Lorestan University of Medical Sciences, Khorramabad, Iran.

2 General Practitioner, Khorramabad, Iran.

3 Lecturer, Faculty of Public Health, Lorestan University of Medical Sciences, Khorramabad, Iran.

Abstract

Introduction:Elevated β-hCG and testosterone levels are found in maternal serum among pregnancies complicated by preeclampsia. The aim of present study is to evaluate the effect of fetal gender on serum human chorionic gonadotropin (β-hCG) and testosterone in normotensive and preeclamptic pregnancies.
 
Methods: Through a cross-sectional study, 139 women with singleton pregnancies in their third trimester were enrolled by convenient classified sampling. They were selected from whom referred to affiliated clinic of Khorram Abad Women’s Hospital for prenatal care between November 2006 and June 2007. Subjects were divided into two groups of normotensive and preeclamptic pregnancies, based on their blood pressure and proteinuria. 71 pregnancies were uncomplicated (35 male and 36 female). 68 pregnancies were complicated by preeclampsia (35 male and 33 female). Human chorionic gonadotropin (β-hCG) and total testosterone were measured in maternal serum. Data were analyzed by SPSS 11.5 software and statistical tests.
 
Results: In male-bearing pregnancies, maternal β-hCG and testosterone serum levels were significantly higher in preeclamptic mothers when compared to normotensive ones (P 
Conclusion: In preeclamptic pregnancies (with both male and female fetus), total testosterone level was higher than that of normotensive ones. Moreover, it was higher in male-bearing women than female-bearing ones. It was just in preeclamptic pregnancies with male fetus, where the maternal serum β-hCG level was higher than that of uncomplicated pregnancies. Our findings, therefore, would implicate an androgenic-mediated mechanism in the development of preeclampsia.

Keywords

References

1. Keay SD, Vatish M, Karteris E, Hillhouse EW, Randeva HS. The role of hCG in reproductive medicine.
BJOG 2004;111(11):1218-28.
2. Steier JA, Bergsjø PB, Thorsen T, Myking OL. Human chorionic gonadotropin in maternal serum in
relation to fetal gender and utero-placental blood flow. Acta Obstet Gynecol Scand 2004;83(2):170-4.
3. Oral E, Genç MR. Hormonal monitoring of the first trimester of pregnancy. Obstet Gynecol Clin North Am
2004;31(4):767-78.
4. Hines M, Golombok S, Rust S, Johnston KJ, Golding J. Testosterone during pregnancy and gender role
behavior of pre-school children: a longitudinal population study. Child Dev 2002;73(6):1678-87.
5. Sterier JA, Myking OL, Bergsj PB. Correlation between fetal sex and human chorionic gonadotropin
in peripheral maternal blood and amniotic fluid in second and third trimester normal pregnancies.
Acta Obstet Gynecol Scand 1999;78:363-71. 
 
6. Elsm A, Hellstr A, Westas M. Fetal gender and gestational age related incidence of preeclampsia.
Acta Obstet Gynecol Scand 2006;85(11):1285-91.
7. Sorensen TK, Williams MA, Zingheim RW, Clement SJ, Hickok DE. Elevated second trimester
human chorionic gonadotropin and subsequent pregnancy induced hypertention. Am J Obstet Gynecol
1993;169:834-8.
8. Acromite MT, Mantzoros CS, Leach RE, Hurwitz J, Doney LG. Androgens in preeclampsia.
Am J Obstet Gynecol 1999;180:60-3.
9. Steier J, Ulstein M, Myking OL. Human chorionic gonadotropin and testosterone in normal and
preeclamptic pregnancies in relation to fetal sex. Obstet Gynecol 2002;100:552-6.
10. Gol M, Altunyurt S, Cimrin D, Guclu S, Bagci M, Demir N. Different maternal serum hCG level
in pregnant women with female and male fetuses: dose fetal hypophyseal adrenal gonadal axis play a role?
J Perinat Med 2004;32(4):342-5.
11. Gol M, Guclu S, Demir A, Erata Y, Demir N. Effect of fetal gender on maternal serum chorionic
gonadotropin levels throughout pregnancy. Arch Gynecol Obstet 2005;237(2):90-2.
12. Basirat Z, Barat S, Hajiahmadi M. Serum beta human chorionic gonadotropin levels and preeeclampsia.
Saudi Med J 2006;27(7):1001-4.
13. Bartha JL, Romero-Carmona R, Escobar-Liompart M, Paloma-Castro O, Comino-Delgado R. Human
chorionic gonadotropin and vascular endothelial growth factor in normal and complicated pregnancies.
Obstet Gynecol 2003;102(5):995-9.
14. Sageshima N, Ishitani A, Omura M, Akasaki M, Umekage H, Katabuchi H, et al. Necrotic feature of the
trophoblasts lacking HLA-G expression in normal and pre-eclamptic placentas. Am J Reprod Immunol
2003;49:174-82.
15. Burton GJ, Hung TH, Jauniaux E. Placenta, hypoxia, hyperoxia and ischemia-reperfusion injury in preeclampsia.
In: Lyall F, Belfort M, editors. Pre-eclampsia: etiology and clinical practice. Cambridge:
Cambridge University Press; 2007. p. 138-40.
16. Salamalekis E, Bakas P, Vitoratos N, Eleptheriadis M, Creatsas G. Androgen levels in the third trimester of
pregnancy in patients with preeclampsia. Eur J Obstet Gynecol Reprod Biol 2006;126(1):16-9.
17. Carlsen SM, Romundatad P, Jacobsen G. Early second trimester maternal hyperandrogenemia and
subsequent preeclampsia. Acta Obstet Gynecol Scand 2005;84(2):117-21.
18. Jirecek S, Joura EA, Tempfer C, Knofler M, Husslein P, Zeisler H. Elevated serum concentrations of
androgens in women with pregnancy-induced hypertension. Wien Klin Wochenschr 2003; 115(5-6): 162-6.
19. Gerulewicz-Vannini D, Camero Y, Salas J, Hernandez-Andrade E. High plasmatic androgen levels in
women affected with pregnancy-induced hypertension. Rev Invest Clin 2006;58(3):228-33.
20. Huhtaniemi IT, Korenbrot CC, Jaffe RB. HCG binding and stimulation of testosterone biosynthesis in
human fetal testis. J Clin Endocrinol Matab 1977;44:963-7.
21. Christine Knickmeyer R, Baron-Cohen S. Fetal testosterone and sex differences. Early Hum Dev
2006;82(12):755-60.
22. Rodeck CH, Gill D, Rosenberg DA, CollinsWP. Testosterone levels in mid-trimester maternal and fetal
plasma and amniotic fluid. Prenat Diagn 1985;5:175-80.
23. Graves JA. Genomic imprinting development and disease- is pre-eclampsia caused by a maternally gene?
Reprod Fertil Dev 1998;10:23-9.
24. Hiby SE, Lough M, Keverne EB, Surani MA, Loke YW, King A. Placenta monoallelic expression of
PEG3 in the human placenta. Hum Mol Genet 2001;10:1093-100.
25. Trupin LS, Simon LP, Eskenazi B. Change in paternity: a risk factor for preeclampsia in multiparas.
Epidemiology 1996;7(3):240-4.
26. Saftlas AF, Levine RJ, Klebanoff MA, Martz KL, Ewell MG, Morris CD, et al. Abortion, changed
paternity, and risk of preeclampsia in nulliparous women. Am J Epidemiol 2003;157(12):1108-14.
27. Feeney JG. Pre-eclampsia and changed paternity. In: Bonnar J, MacGillivary I, Symonds M, editors.
Pregnancy hypertention. Lancaster: MTP Press limited; 1980. p. 41-4.
28. Hjartardottir S, Leifsson BG, Geirsson RT, Steinthorsdottir V. Paternity change and the recurrence risk in
familial hypertensive disorder in pregnancy Hypertens Pregnancy 2004;23(2):219-25. 

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