Effect of Glucose Ingestion on Non-Stress Test Parameters

Document Type : Original Article


1 M.Sc. in Midwifery, Faculty Member, Azad Islamic University, Larestan Branch, Larestan, Iran

2 M.Sc. in Midwifery, Faculty Member, Faculty of Nursing and Midwifery, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran

3 Associate Professor of Obstetrics & Gynecology, Razi Hospital, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran

4 M.Sc. in Biostatics, Faculty of Health, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran


Introduction: The most common test used in third-trimester of pregnancy in order to check fetal wellbeing is the non-stress test (NST).One of the disadvantages of NST is its high rate of false-positive results. The most common cause of a nonreactive test is a period of fetal inactivity or quiet sleep. Many different methods have been tried to decrease the number of nonreactive NSTs. Probably the most common method of provoking fetal reaction is maternal ingestion of fruit juice as a source of glucose. The aim of this study is to determine whether maternal oral glucose ingestion influences non-stress test indices.
Methods: A clinical trial study was performed at Amir-al-momenin hospital in Ahvaz on 35 primiparous non-laboring healthy women with normal singleton pregnancy at 37-40 weeks of gestation. All women had a normal oral glucose tolerance test at 24-28 weeks of gestation. The women were evaluated in a fasting state (last meal more than 3 hours before non-stress test). The NSTs were performed 1 hour after oral ingestion of 50g of glucose in 240ml of water in first day and an equal volume of water during second day. Statistical analysis was performed using a paired t-test and chi-square test and p<0.05 was considered significant.
Results: There was no significant difference in fetal heart rate baseline, number and amplitude of fetal heart rate accelerations, beat to beat variability and number of variable decelerations among women whether receiving glucose or water (p>0.05).However, there was an increase in duration of fetal heart rate acceleration followed by oral ingestion of glucose (p<0.01).
Conclusion: Maternal oral glucose ingestion is not able to reduce the false-positive results of non-stress tests.


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