The Correlation of Oral Contraceptive Pills (OCPs) use and Depression

Document Type : Original Article

Authors

Instructor of Midwifery, Islamic Azad University, Touyserkan Branch, Touyeserkan, Iran

Abstract

Introduction: Oral Contraceptive Pills (OCPs) are the most commonly form of reversible contraception used throughout the world. While use is prevalent, discontinuation rate of oral OCP is high. Mood disturbance has been identified as a side effect of OCP use and is of such concern to many women that is has resulted in their discontinuation of OCP use. The purpose of this study was to investigate the correlation of oral contraceptive pills and depression in women.
 
Methods: This descriptive study was performed on 410 women who referred to Tamin-Ejtemaei hospital of Hamadan from May to October 2009. Samples were selected using by randomized systematic method and were randomly divided into OCP (205) and non-OCP (205) groups. The assessment tool was two-part questionnaire containing the demographics data and short depression scale data. Data were analyzed by Chi-square and fisher’s test and using SPSS 14 software.
 
Results: There was significant correlation between OCP use and depression score (p=0.006) and difference between depression score and increase of OCP use duration was significant (p=0.01).
 
Conclusion: OCP users might be more vulnerable to depression.

Keywords


1.  Duke JM, Sibbritt DW, Young AF. Is there association between the use of oral  contraception
and depressive symptoms in young Australian women? Contraception 2007 Jan;75(1):27­31. 
2.  O’Connell K, Davis AR, Kerns J. Oral contraceptives: side effect  and depression in adolescent 
girls. Contraception 2007 Apr;75(4):299­304. 
3.  Kulier  R, Helmerhorst FM, Maitra N,  Gulmezoglu AM. Effectiveness and acceptability of 
progestogens  in combined oral  contraceptives  – a systematic review.  Reprod Health 2004
Jun3;1(1):1. 
4.  Sanders  SA,  Graham CA,  Bass  JL,  Bancroft  J.  A prospective study of the effects  of  oral  contraceptives  on sexuality and well­being and their  relationship to discontinuation.  Contraception 2001 Jul;64(1):51­8. 
5.  Redmond G,  Godwin AJ, Olson W,  Lippman JS. Use of placebo controls in an oral  contraceptive trial:  methodological issues  and adverse event incidence.  Contraception 1999
Aug;60(2):81­5.  6.  Joffe H, Cohen LS, Harlow BL. Impact  of oral  contraceptive pill  use on premenstrual mood: 
predictors of improvement and deterioration. Am J Obstet Gynecol 2003 Dec;189(6):1523­30. 
7.  Stenchever  MA, Herbst AL,  Droegemueller W, Mishell D.  Comprehensive gynecology.  St.Louris:Elsevier Health Sciences;2001:309.  8.  Kulkarni J,  Liew J, Garland KA. Depression associated with combined oral contraceptive­­a pilot study. Aust Fam Physician 2005 Nov;34(11):990. 
9.  Oinonen KA, Mazmanian D. To what extent do oral contraceptives influence mood and affect? J 
Affect Disord 2002 Aug;70(3):229­40.  10.  Kahn LS, Halbreich U. Oral  contraceptives  and mood.  Expert  Opin Pharmacother  2001
Sep;2(9):1362­82.