Assessment of nutrients intake in polycystic ovary syndrome women compared to healthy subjects

Document Type : Original Article

Authors

1 Associate Professor of Nutrition, Nutrition Research Center, Faculty of Health & Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

2 M.Sc of Nutrition, Faculty of Health & Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran

3 Professor of Nutrition, Faculty of Health & Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

4 Associate Professor of Obstetrics & Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

5 M. Sc of Statistics & Epidemiology, Faculty of Health & Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Introduction: Nutritional deficiencies and nutrient intake are determinants of the onset of polycystic ovary syndrome (PCOS). In spite of this, nutrients intake has not been much studied in these patients. Therefore, this study was carried out to assess nutrient intake and food consumption in PCOS subjects and compare it to healthy women.
 
Methods: This case-control study was carried out on 60 women (30 PCOS patients and 30 healthy women) who were selected by simple randomized sampling method, after BMI unification in Tabriz Al-Zahra Hospital in 2009. Individuals’ intake was assessed by using three 24 recall questionnaires and food frequency questionnaire. Data were analyzed by Nutrition III and SPSS 13 software using descriptive analysis and independent t test.
 
Results: Mean of energy, carbohydrate, fat, protein, magnesium, calcium and vitamin D intake were higher in healthy subjects than patients (p<0.05). Intake of sodium, zinc, chrome, folate, B12, simple sugars and dietary fiber were not different among two groups. Frequency of milk and dairy products, fruits and nuts consumption in patients were less than the control group (p<0.05).
 
Conclusion: Low intake of Calcium, Magnesium, vitamin D, dairy products, fruits and nuts is noticeable in PCOS women. Considering the effects of mentioned nutrients in metabolic disorders, it is necessary to give nutritional counseling for more intake of these nutrients in PCOS patients.

Keywords


1. Speroff L, Glass RH, Kase NG. Clinical gynecologic endocrinology and infertility. 6th ed. Baltimore:
Lippincott Willims & Wilkins. 1999; PP: 1097-1133.
2. Duškov M, Strka L. The Existence of a Male Equivalent of the Polycystic Ovary Syndrome the Present
State of the Issue. Prague Med Rep 2006; 107 (1) 17–25.
3. Diamanti-Kandarakis E, Dunaif A. New perspectives in polycystic ovary syndrome. Trends Endocrinol
Metab 1996; 7(8): 267–271.
4. Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol
1935; 29 (2):181-191.
5. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on
diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil & Steril 2004;
81(1):19-25.
6. Colditz GA, Manson JE, Stampfer MJ, Rosner B, Willett WC, Speizer FE. Diet and risk of clinical diabetes
in women. Am J Clin Nutr 1992; 55(5):1018–1023.
7. Salmerón J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC. Dietary fiber, glycemic load,
and risk of non-insulin-dependent diabetes mellitus in women. JAMA 1997; 277(6): 472–477.
8. Hirschler V, Oestreicher K, Beccaria M, Hidalgo M, Maccallini G. Inverse association between insulin
resistance and frequency of milk consumption in low-income Argentinean school children. J Pediatr 2009;
154(1):101-105.
9. Choi H, Willett WC, Stampfer MJ, Rimm EB, Hu FB. Dairy consumption and risk of type 2 diabetes
mellitus in men: a prospective study. Arch Intern Med 2005; 165 (9): 997–1003.
10. Pereira MA, Jacobs DR Jr, Van Horn L, Slattery ML, Kartashov AI, Ludwig DS. Dairy consumption,
obesity and the insulin resistance syndrome in young adults: the cardia study. JAMA 2002; 287 (16):2081–
2089.
11. Adebamowo CA, Spiegelman D, Danby FW, Frazier AL, Willett WC, Holmes MD. High school dietary
dairy intake and teenage acne. J Am Acad Dermatol 2005; 52 (2):207–214.
12. Wild RA, Painter PC, Coulson PB, Carruth KB, Ranney GB. Lipoprotein lipid concentrations and
cardiovascular risk in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1985; 61(5):946 –
951.
13. Douglas C, Norris L, Oster R, Darnell B, Azziz R, Gower BA.Difference in dietary intake between women
with polycystic ovary syndrome and healthy controls. Fertil & Steril 2006; 86(2): 411-417.
14. Colombo O, Pinelli G, Comelli M, Marchetti P, Sieri S, Brighenti F, Nappi RE, Tagliabue A. Dietary
intakes in infertile women a pilot study. Nutr J 2009; 8 (53): 1-9.
15. Kilic-Okman T, Guldiken S, Kucuk M. Relationship between Homocysteine and insulin Resistance in
women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004; 51(5): 505-508.
16. Mahan K, Scott SS. Principles of Nutrition. Translated by Shidfar F, Kholdi N. Tehran: Jameanegar
Publications. 2nd ed. 2009; pp: 338-345.
17. Hatfield JA. Comparison of dietary intake between obese, post-obese, and normal weight women [masters
thesis]. Birmingham (AL): Univ. of Alabama at Birmingham, 2000.
18. Micic D, Macut D, Popovic V, Sumarac-Dumanovic M, Kendereski A, Colic M, Dieguez C, Casanueva FF.
Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome.
Gynecol and Endocrinol 1997; 11(5): 315-320.
19. Clayton RN, Ogden V, Hodgkinson J. How common are polycystic ovaries in normal women and what is
their significance for the fertility of the population? Clin Endocrinol 1992; 37(2):127-134.
20. Carmina E, Legro RS, Stamets K, Lowell J, Lobo RA. Difference in body weight between American and
Italian women with polycystic ovary syndrome: influence of the diet. Hum Reprod 2003; 18(11): 2289 –
2293.
ٍManson JE, Stampfer MJ, Rosner B, Willett WC, Speizer FE. Diet and risk of clinical diabetes
in women. Am J Clin Nutr 1992; 55 (5):1018 –1023.
22. Salmerón J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, Willett WC. Dietary fiber, glycemic load,
and risk of non-insulin-dependent diabetes mellitus in women. JAMA 1997; 277(6):472–477.
23. Espeland MA, Whelton PK, Kostis JB, Bahnson JL, Ettinger WH, Cutler JA. Predictors and mediators of
successful long-term withdrawal from antihypertensive medications. Arch Fam Med 1999; 8(3):228 –236.
24. Ortlepp JR, Metrikat J, Albrecht M, vonKorff A, Hanrath P, Hoffmann R. The vitamin D receptor gene
variant and physical activity predicts fasting glucose levels in healthy young men. Diabet Med 2003;
20(6):451–454.
25. Bourlon PM, Billaudel B, Faure-Dussert A. Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin
D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol 1999;
160(1):87–89.
26. Billaudel BJ, Bourlon PM, Sutter BC, Faure-Dussert AG. Regulatory effect of 1,25-dihydroxyvitamin D3
on insulin release and calcium handling via the phospholipid pathway in islets from vitamin D–deficient
rats. J Endocrinol Invest 1995; 18(9):673–682.
27. Mahan LK, Escott- Stump S. Krause Food & Nutrition Therapy. 12th ed. St. Louis: Saunders Elsevier,
2008; PP: 132-134.
28. McCarty MF. Insulin secretion as a potential determinant of homocysteine levels. Med Hypotheses 2000;
55(5):454-455.
29. Setola E, Monti LD, Galluccico E, Palloshi A. Insulin resistance and endothelial function are improved
after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between
homocysteine levels and hyperinsulinemia. Eur J Endocrinol 2004; 151(4): 483-489.