Comparative Effect alone Honey and Mix with Chlotrimazol on Vaginitis Candidacies

Document Type : Original Article

Authors

1 M.Sc. of Midwifery, Faculty of Nursing and Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran.

2 M.Sc. of Health Education, Faculty of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran.

3 Ph.D. in Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

4 M.Sc. of Vital Statistics, Research center of natural products safety and medicinal plants, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Abstract

Introduction: Vulvovaginal candidiasis (VVC) is the most common vaginitis among women. The purpose of this study was comparing the efficacy of honey and clotrimazol 100 mg on vaginitis candidiasis. To evaluate the efficacy and tolerability of clotrimazol and honey or both, they were used for 7 days in the treatment of vaginitis candidiasis.
 
Methods: This double-blind clinical trial was conducted on 77 non-pregnant women aged 18 to 49 years with vaginitis candidiasis. Fifteen patients were in the honey group (Group 1), 30 in the honey and clotrimazole group (Group 2), and 32 in the clotrimazole group (Group 3). Participation in the study using vaginal clotrimazole and vaginal honey or both daily for 7 days. Baseline diagnosis consisted candidiasis culture together with clinical diagnosis and declaration of signs by the patients. Gynecological and microbiological tests confirmed the diagnosis, and patients were followed up for 7 and 21 days after the onset of treatment. Student t-test and chi-square statistical tests were used for data analysis.
 
Results: Alleviations occurred in symptoms and signs of vaginitis after treatment with honey and clotrimazole. The success rate for the treatment of vaginitis candidiasis was 100% in groups 1 and 2; seven and 30 days after intervention, the success was well observed in comparison with group 3, and the difference was significant (p<0.001). The medication was well tolerated.
 
Conclusion: Use of honey alone represents a novel and effective formulation for the treatment of vaginitis. Also, a combination of 100 mg of clotrimazole and 5ml of honey application was found to be effective in the treatment of the most common vaginitis.

Keywords

References

1. Taghizadeh Z. Darsnameh jameh mamayi. Tehran nashr andisheh rafi 2005 first print pp 32-34.
2. Ayyildiz A, Akgul KT, Celbeci O, Nuhoglu B, Caydere M, Ustun H, et al. Intraurethral honey application
for urethral injury; an experimental study. Int Urol Nephrol 2007; 39(3): 815-21.
3. Irish J, Carter DA, Shokohi T, Blair SE. Honey has as antifungal effect against candida species. Med
Mycol; 2006; 44 (3) ; 289-91.
4. VardiA. BarzilayZ, Linder N, Cohen HA , ParetG, Barzilai A. Local application of honey for treatment of
neonatal postoperative wound infection. Acta Paediatr 1998; 87 (4); 429-32. 
 
5. Al-Waili NS. Investigating the antimicrobial activity of natural honey and its effects on the pathogenic
bacterial infections of surgical wounds and conjunctiva. J Med Food 2004; 7 (2):210-22.
6. Theunissen F, Grobler S, GedaliaI. The antifungal action of three South African honeys on Candida
albicans. Apidologie 2001; 32: 371-9.
7. Dunford C, Cooper R, Molan P, White R. The use of honey in wound management. Nurs Stand
2000;15(11):63-8.
8. Cooper RA, Molan PC, Harding KG. Antibacterial activity of honey against strains of staphylococcouse
aureus from infected wounds. J R Soc Med 1999 ;92(6):283-5.
9. 9- Gallez LM, Fernández LA.Honeys from Ventania system: microbiological quality evaluation at different
points of honey-processing. Rev Argent Microbiol 2009; 41(3): 163-7.
10. khadam R. Application drug iran generic ,dibaj nashr11- Phuapradit W, Saropala N. Topical application of
honey in Treatment of abdominal wound disruption. Aust N Z JObstet Gynaecol 1992:32(4): 381-4.
11. Punford c, cooper R, Molan P, white. R The use of honoy in wound manay ement. Nars stand. 2000 Nov
29-Dec 5; 15(11): 63-8.
12. Engberts MK, Korporaal H, Vinkers M, van Belkum A, van Binsbergen J, Lagro-Janssen T, et al..
Vulvovaginal candidiasis: diagnostic and therapeutic approaches used by Dutch general practitioners. Eur J
Gen Pract. 2008;14(1):30-3.
13. Zawadzki J, Suchy H, Scheller S. Use of propolis for treatment of vaginitis and cervicitis. Przegl Lek
1973;30:620-3.
14. Boukraâ L, Bouchegrane S. Additive action of honey and starch against Candida albicans and Aspergillus
niger. Rev Iberoam Micol 2007 31;24(4):309-11.
15. Sobel JD, Wiesenfeld HC, Martens M, Danna P, Hooton TM, Rompalo A, et al. Maintenance Fluconazole
Therapy for Recurrent Vulvovaginal Candidiasis. N Engl J Med. 2004;351(9):876-83.
16. Okeniyi JA, Olubanjo OO, Ogunlesi TA, Oyelami OA. Comparison of healing of incised abscess wounds
with honey and eusol dressing. J Altern Complement Med 2005:11(3):511-3.
17. Yuzbasioglu MF, Kurutas EB, Bulbuloglu E, Goksu M, Atli Y, Bakan V, et al. Administration of honey to
prevent peritoneal adhesions in a rat peritonitis model. Int J Surg 2009; 7(1): 54-7.
The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 14, Issue 8 - Serial Number 8
February 2012
Pages 48-54

Files

Share

How to cite

Statistics