Comparison of Effects of Hyoscine N-Butyl Bromide and Promethazine on Length of Active Phase of First Stage of Labor

Document Type : Original Article

Authors

1 Lecturer of Midwifery, Faculty of Nursing and Midwifery, Mashhad University of Medical sciences, Mashhad, Iran.

2 Lecturer of Nursing, Faculty of Nursing and Midwifery, Birjand University of Medical sciences, Birjand, Iran.

3 . Associate Professor of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.

4 B.Sc. of Midwifery, Omol Banin Hospital, Mashhad University of Medical sciences, Mashhad, Iran.

Abstract

Introduction: Shortening duration of delivery without endangering mother and fetus is always highly considered by obstetric specialist and mothers. Widely use of Hyoscine N-butyl bromide and Promethazine in hospitals and limited researches with conflicting results in this regard made us investigate the efficiency of Hyoscine N-butyl bromide and Promethazine on length of active phase of the first stage of labor.
Methods: A provident double-blind clinical trial was done on 188 nulliparous women. They were classified into the Hyoscine N-butyl bromide (48cases), Promethazine (45cases) and control (95 cases) groups. The samples were randomly allocated from cases who were injected 20 mg of Hyoscine N-butyl bromide, 25 mg of Promethazine IM in dilatation 3-5cm, and control group in which no medicine was used. Data analysis was performed using SPSS software version 16, t- test, chi-square and ANOVA tests. p<0.05 was considered significant.
Results: The mean duration of active phase of labor in Promethazine (5.69±3.45) was shorter than in control group (7±3.44). This difference was statistically significant (p=0.049). However duration of active phase of labor had no statistically significant difference between Hyoscine N-butyl bromide and control groups (p=0.205). However, the mean duration of active phase of labor was not statistically significant in the three groups of Hyoscine N-butyl bromide, Promethazine and control (p=0.140).
Conclusion: It seems that Promethazine can be used as an effective drug to shorten the length of laboring in comparison with Hyoscine N-butyl bromide.

Keywords

References

1. Gupta B, Nellore V, Mittal S. Drotaverine hydrochloride versus hyoscine-N-butylbromide in augmentation of labor.
Int J Gynaecol Obstet 2008 Mar;100(3):244-7.
2. Beischer; NA, Mackay EV. Obstetrics and newborn: an illustrated textbook. 3rd ed. London:Saundres;1995.
3. Saatsaz S, Haji Ahmadi M, Basirat Z. [Effect of atropine, promethazine and pethidine on the active phase of labor]
[Article in Persian]. J Babol Univ Med Sci 2007;9(3):39-42.
4. Eravani M, Bekhradinasab H. [Effect of intravenous hyoscine on the delivery process] [Article in Persian]. J Med Sci
Health Ser Shahid Sadoughi Yazd 2005;13(5):59-64.
5. Abdalla FM, Abreu LC, Porto CS. Effect of estrogen on intracellular signaling pathways linked to activation of M(2)-
and M(3)- muscarinic acetylcholine receptors in the rat myometrium. Mol Cell Endocrinol 2000 Feb;160(1-2):17-24.
6. Katzung BG. Basic and clinical pharmacology. 3rd ed. St Louis:Appletone & Lange;1998:268.
7. Rabiei S, Shaabani M. [A Comparative study of the effect of atropine and promethazine on the labor process]
[Article in Persian]. J Sabzevar School Med Sci 2001;7(4):73-7.
8. Mortazavi FS, Rakhshani MH. [The effect of atropine, hyoscine and promethazine on the length and speed of
delivery in multiparous] [ Article in Persian]. J Gorgan Univ Med Sci 2004;14:92-6.
9. Panahi M, Ghorbanpour P, Alaei M, Khatibi A. [Iran generic drugs]. Tehran:Samat Publishing;2000. [In Persian].
10. Aggarwal P, Zutshi V, Batra S. Role of hyoscine N-butyl bromide (HBB, buscopan) as labor analgesic. Indian J Med
Sci 2008 May;62(5):179-84.
11. Abd El-Rahim Dandarawy A. Efficacy of hyoscine butylbromide on the phases of cervical dilatation [Thsis in
Arabia].Abbassyia:Faculty of Medicine Ain Shams University:2008..
12. Sirohiwal D, Dahiya K , De M. Efficacy of hyoscine-N-butyl bromide (Buscopan) suppositories as a cervical
spasmolytic agent in labour. Aust N Z J Obstet Gynaecol 2005 Apr;45(2):128-29.
13. Bhatttacharya P, Joshi SG. Acceleration of intramuscular ‘Buscopan’ injection. J Obstet Gynecol Ind 1985;35:1014-7.
14. Samal S, Gupta U, Wable M. Buscopan (Hyoscine-NButylbromide) in acceleration of labour. Ind Med. Gaz
1998;82:8-10.
15. Samuels LA, Christie L, Roberts-Gittens B, Fletcher H, Frederick J. The effect of hyoscine butylbromide on the first
stage of labor in term pregnancies. BJOG 2007 Dec;114(12):1542-6..
16. Lopez-Zeno JA, Peaceman AM, Adashek JA, Socol ML. A controlled trial of a program for the active management
of labour. N Engl J Med 1992 Feb 13;326(7):450-4.
17. Baracho HM, Kamat JR, Kunalhekar JI. Buscopan in acceleration of labor. J Obstet Gynecol Ind 1984;34:509-12.
18. Makvandi S, Tadayon M, Abbaspour M. Effect of hyoscine-N-butyl bromide rectal suppository on labor progress in
primigravid women: a randomized double-blind placebo-controlled clinical trial. Croat Med J 2011 Apr;52(2):159–63.
19. Shenker L. Clinical experiences with fetal heart rate monitoring of one thousand patients in labor. Am J Obstet
Gynecol 1973 Apr 15;115(8):1111-6.
20. Boehm FH, Growdon JH. The effect of scopolamine on fetal heart rate baseline variability. Am j Obstet Gynecol
1974 Dec 15;120(8):1099-1104.
21. Ayromlooi J, Tobias M, Berg P. The effects of scopolamine and ancillary analgesics upon the fetal heart rate
recording. J Reprod Med 1980 Dec;25(6):323-6.
22. Dunwoodie D, Glare P. Antiemetic Drugs. Chapter 144: 785-796.
23. Ron M., Menashe M, Hochner-Celnikier D, Palti Z. Maternal blood pressure response to the intravenous
administration of pethidine-promethazine during labor. Europ. J Obstet Gynecol reprod. Biol 1984 Sep;18(1-2):25-8.
24. Pajntar M, Valentincic B, Verdenik I. The effect of pethidine hydrochloride on the cervical muscles in the active
phase of labour. Clin Exp Obstet Gynecol 1993;20(3):145-50.
25. Vella L, Francis D, Houlton P, Reynolds F. Comparison of the antiemetics metoclopramide and promethazine in
labour. Br Med J (Clin Res Ed) 1985 Apr 20;290(6476):1173-75.

Files

Share

How to cite

Statistics