Vaginal and Sublingual Misoprostol for Termination at Second Trimester Pregnancy in Patients with Previous Cesarean Section

Document Type : Original Article

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Resident of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Associate Professor, Department of Biostatistics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 B.Sc. of Midwifery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: Abortion is a medical or surgical termination of pregnancy before the fetus is able to survive. Because of surgical complications, medical treatments are most commonly used. Since misoprostol (a prostaglandin E1 analogue) is cheaper, effective, and easily administrated by different methods, has been widely prescribed. The aim of this study was to evaluate vaginal and sublingual misoprostol for termination at second trimester pregnancy in patients with previous cesarean section.
Methods: This analectic-descriptive study was held on 70 pregnant women with previous cesarean section who referred for termination at second trimester pregnancy to Mashhad University of medical sciences academic hospitals. They were randomly divided into two groups of vaginal misoprostol 400μg max dose of 1600 μg and sublingual misoprostol 400 μg, next dose of 200 μg, and max dose of 1600 μg. Abortion complications and outcomes were analyzed in every individual. P value less than 0.05 was considered statistically significant.
Results: Mean age of patients was 29.25±5.48 years. Mean of reproductive age in all patients was 17.90±4.31 weeks (range 14-29 weeks). In each groups 3 persons (9%) had fever. Nausea was observed in 5 persons (7%) (4 people in vaginal and one person in sublingual group). There was no significant difference between two groups (p>0.05). Among the cases, no one needed to undergo curettage and no one had uterus rupture.
Conclusion: Prescription of vaginal and sublingual misoprostol for medical termination of pregnancy at second trimester in person with previous cesarean section had less complication, and is very effective.

Keywords

References

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