The Relationship of Iron Deficiency Anemia with Preterm delivery in Pregnant Women Referred to Health Centers of Tabriz: A Case-Control Study

Document Type : Original Article


1 Bachelor student of Midwifery, Student Research Committee, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

2 PhD student of Research, Tabriz Health Services Management Research Center, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Bachelor of Midwifery, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

4 M.Sc. student of Midwifery, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.


Introduction: Preterm delivery is a major cause of neonatal mortality and morbidity. In most studies, preterm delivery has a little increased in pregnant women with anemia, However, not all studies have confirmed this finding. This study was conducted with aim to determine the relationship between iron deficiency anemia and preterm delivery.
Methods: This case-control study was performed on 162 pregnant women with preterm delivery and 162 subjects without preterm delivery referred to health centers of Tabriz from 2011-2014. Iron deficiency anemia was determined by hemoglobin and hematocrit indexes. To investigate the relationship between iron deficiency anemia and preterm delivery, some risk factors with inclusion and exclusion criteria and some through the matching of groups were controlled. Other possible personal and fertility risk factors were controlled through logistic regression and their odds ratio were determined. Data were analyzed using SPSS statistical software (version 19), and Chi-square test, Independent t-test, and Logistic regression. PResults: In the evaluation of 5260 pregnant women, it was found that 214 (4.06%) had preterm delivery. Index of hematocrit between 26-30 weeks (P=0.01 and OR (CI95%)=0.89(0.81­­-­­­­­­­0.97)), anemia in 26-30 weeks (P=0.03 and OR (CI95%)=3.26(1.09-9.72)) and the pattern of weight gain according to BMI (P<0.05) were the risk factors for preterm delivery.
Conclusion: Considering the relationship between preterm delivery and anemia during 26-30 weeks of gestation, educating, prevention and early diagnosis of anemia may have effective role on reducing the risk of preterm delivery.


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