Frequency of hyperprolactinemia in patients with hirsutism

Document Type : Original Article

Authors

1 Assistant professor, Department of Skin and Hair Diseases, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

2 Assistant professor, Department of Obstetrics and Gynecology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

3 Assistant Professor, Department of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

4 General Physician, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Abstract

Introduction:Hirsutism is one of the major problems in women referring to skin clinics. One of the causes of hirsutism is hyperprolactinemia. This study was performed with aim to evaluate the changes in prolactin hormone in women with this disease.
Methods:This cross-sectional study was performed on  200 patients with hirsutism referring to skin clinic of Babol Yahyanejad Hospital in 2013. At the second or third day of menstruation, experiments were performed for all the patients to determine hormone levels. Finally, 200 patients without PCOS were studied. Also, a questionnaire including a careful history and physical examination was scheduled for all the patients. Data was analyzed by SPSS statistical software (version 16). P
Results:Twenty five patients (12.5%) had Hyperprolactinemia. No significant relation was found between hyperprolactinemia with marital status, history of galactorrhea, family history of hirsutism and infertility (P>0.05). However, significant difference was observed between hyperprolactinemia and menstrual disorders (P=0.043).
Conclusion: Although hyperprolactinemia is a rare cause of hirsutism, but its prevalence was high in this study. Therefore, evaluation of blood prolactin levels should be considered in hirsute patients.

Keywords


  1. Azziz R. The evaluation and management of hirsutism. Obstet Gynecol 2003;101 (5 Pat 1):995-1007
  2. Clayton RN, Oyden V, Hodgkinson S. How common are PCO in normal women and what is their significance for the fertility of the population?. Clin Endocrinol 1992;37(2:127-34.
  3. Clarke Secor RM.Hirsutism in women. Clinician Reviews 2000;10(2): 61-72.
  4. Acucion M, Culvo PM, San millan JL, Sancho J, Avla S, Esceber HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from spain. J Clin Endocrinol Metab 2000;85(7):2434-8.
  5. Tirgar Tabari S, Haji Ahmadi M, Gholi Nejad N, Talebzadeh Noori Z. Frequency of Hirsutism among females students in Babol University of Medical Sciences, 1999. J Babol Univ Med Sci 2002; 4(1): 20-4.(Persian).
  6. Yazdanfar A, Beyhaghi Z, Manoochehrian N. Prevalence of hirsutism in female students of Hamedan University of medical sciences.  Scientific Journal of Hamadan University of Medical Sciences & Health Services 1997; 4 (8) : 26-32.
  7. Berek JS, Adashi EY, Hillard PA, Novak S. Gynecology. 13th ed. Philadelphia: Waverly; 2007.P.149-72.
  8. Champion R, Burton J, Burns D, Breathnach S. Text book of dermatology. 6th ed. London: Black well Science LTD; 1998.P.2895-903.
  9. Copeland LJ. Study Guide for text book of gynecology. 1st ed. Newyork: sunders;  1994. P. 420-40.
  10. Odem R. Andrews disease of the skin: clinical dermatology. 9th ed. Philadelphia: WB Sunders; 2000.P.964-67.
  11. Bernasconi D, Del Monto P, Meozzi M, Randazzo M, Marugo A, Badaracco B, et al. The impact of obesity on hormonal parameters in hirsute and nonhirsute women. Metabolism 1996;45(1):72-5.
  12. Speroff I, Glass R, Kase N. Clinical gynecologic endocrinology and infertility. 6th ed. Philadelphia:Lippincott Williams & Wilkins; 2005.P.897-9.
  13. Farnaghi F, Seyrafi H, Zarrinpour N. Descriptive study of 110 patients with Hirsutism in Tehran Razi Hospital during the years 2000-01. Iran J Dermatol 2002; 6(21): 21-5.
  14. Rahiminejad M,   saleh A,   Jandaghi Amirabadi Y. Evaluation of serum level of testosterone , Dehydroepiandrosterone - sulphate (DHEA-S) prolactin , Luteinizing Hormone (LH) Follicle – stimulating hormone (FSH) in women with hirsutism. Pars  J Univ Med Sci 2008; 5(2): 7-14.
  15. Ahmad GM, Shah IH, Sameem F, Kamili Q, Sultan J. Hirsutism in Kashmir: an etiological study. Indian J Dermatol 2009:54(1):80-2.
  16. Ghaderi R, Sharifzadeh GH, Javanbakht P. Hirsutism and related factors. Birjand Med Sci Univ J 2004;11(1):19-23.(Persian).
  17. Mehta A, Matwijiw I, Taylor P. Should androgen levels be measured in hirsute women with normal menstrual cycles?. Int J Fertil 1992; 37(6):354-7.
  18. Berker DAR, Messenger AG, Sinclair RD. Disorder of hair. In: Burns T, Breathnach S, Cox N, Griffiths C. Text Book of Dermatology. 7th ed. Oxford: Blackwell Publishing; 2004.P.63.
  19. Heydari M, Niroomanesh SH, Hajizadeh E. Study the menstrual pattern and score of hirsutism hyperprolactinemic hirsute women. Daneshvar Med  2004; 11(49);13-18.(Persian).
  20. Aziz R, Sanchez LA, Knochenhauer ES, Moran C, Lazenby J, Stephens KC, et al. Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab2004; 89(2):453-62.
  21. Carmina E, Rosato F, Janni A, Rizzo M, Longo RA. Relative prevalence of different androgen excess  disorders in 950 women referred because of clinical hyperandrogenism. J Clin Endocrinol Metab 2006; 91(1):2-6.
  22. Isik AZ, Gulekli B, Zorlu CG, Ergin T, Gokmen O. Endocrinological and clinical analysis of Hyperprolactinemia patients with and without ultrasonically diagnosed polycystic ovarian changes. Gynecol obset Invest 1997; 43(3):183-5.
  23. Zargar AH, Laway BA, Masoodi SR, Bhat MH, Wani AI, Bashir MI, et al. Clinical and etiological profile of Hyperprolactinemia – Data from a tertiary care center. J Assoc Physicians India 2005; 53:88-290.
  24. Biller BM. Hyperprolactinemia. In J Fertil Women Med 1999; 44(2):74-7.