Comparative study of serum level of vitamin D in pregnant women with preeclampsia and normal pregnant women

Document Type : Original Article


1 Associate professor, Department of Obstetrics and Gynecology, Women's Health Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Resident of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Introduction: Epidemiologic events show the associations of vitamin D deficiency andhypertension, cardiovascular disease and some cancers.Vitamin D is diagnosed as one of the molecules in the pathogenesis of preeclampsia. This study was performed with aim to evaluate serum level of maternal 1 and 25-hydroxyvitamin D and its relationship with preeclampsia.
Methods: This case-control study was performed on 70 mothers referred to Mashhad University hospitals from 2013 to 2014. The study was conducted on two groups of normal pregnant women and women with severe preeclampsia. The blood samples were assessed for vitamin D serum level. Data analysis was performed using the SPSS software (version 16), and student-t and Chi-square test. P < 0.05 was considered significant.
Results: The mean serum vitamin D in case group was 5.5±3.32 (range 3-23) and in control group was 8.05±4.81 (range 3-37). T-test showed a significant difference between two groups in terms of mean serum vitamin D (P<0.001).
Conclusion: According to the findings in this group, vitamin D deficiency was found in both groups. Vitamin D deficiency in case group is so that has caused severely clear difference. It is recommended that the study be conducted with larger sample size before pregnancy, the mothers be evaluated in terms of vitamin D level and supplement be provided to the deficient patients, and severe preeclampsia will be checked.


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