A low-grade chronic inflammation in polycystic ovary syndrome: Role of interleukin-1 alpha, 1 beta, 17A and TNFα

Document Type : Original Article


1 Assistant Professor, Vali-e-Asr Reproductive Health Research Center, Vali-e-Asr Hospital, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

2 Assistant Professor, Department of Pathology, School of Medicine, Pathology laboratory of Vali-e-Asr Hospital, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

3 Instructor, Department of Community Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.

4 MSc. of Midwifery, Vali-e-Asr Reproductive Health Research Center, Vali-e-Asr Hospital, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.


Introduction: Polycystic ovary is a range of endocrinal and metabolic disorders in the complicated patients. Studies in recent decades report that chronic low-grade inflammation is due to this syndrome being long-term. This study was performed with the aim to evaluate the role of the immune system and the regulatory role of cytokines of Tumor necrosis factor-alpha, Interlukins of 1alpha, 1beta, and 17 A in the patients with polycystic ovary in order to more knowing about these relationships be effective in the etiology or cause of polycystic ovary syndrome and consequently, effective drug-therapy be possible.
Methods: This study was performed on the patients referred to …. Infertility center in 2012. 85 patients with infertility caused by polycystic ovarian syndrome were placed in intervention group and 86 cases in control group. Four cytokines of 1alpha, 1beta, 17 A and tumor necrosis factor alpha were evaluated in blood serum of both groups. Data was analyzed using SPSS software (version 19), and t test, chi-square and Mann-Whitney tests. PResults: Interlukin 1 (alpha, beta) was higher PCO group than control group, this difference was completely clear in interleukin 1α (P<0.001) and increased interleukin 1beta was also significant (P=0.017). Inflammatory mediator of IL-17 was significantly lower in serum of patients with PCOS than control group (P<0.001). TNFα mediator showed no significant change in two groups (P=0.119).
Conclusion: Polycystic ovaries can be a mild chronic inflammatory disease. Because cytokines 1 alpha and beta, particularly alpha, show greatly increased in these patients.


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