Effect of Leptin on weight gain in pregnant women: A systematic review

Document Type : Review Article


1 M.Sc. student, Department of Midwifery and Reproductive Health, School of medical sciences, Tarbiat Modares University, Tehran, Iran

2 Assistant professor, Department of Midwifery and Reproductive Health, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


Introduction: Pregnancy is a condition associated with decreased thermogenesis leading to increased body fat mass. In early pregnancy, lypogenesis routes are dominant that seems it is by hormones such as Leptin, while at the end, lipolysis molecular routes are more active. The key role of Leptin in animals and humans is regulating body fat which its levels increases with increased gestational age, peaks in second trimester and stays platue untill term. This systematic review was performed with the aim to summarize the studies related to leptin and weight gain during pregnancy.
Methods: in this study, 56 abstract and full text articles were obtained from electronic research by entering the desired keywords in Sciencedirect, Pubmed, Googlescholar,Yahoo, Iranmedex and SID databases since 1995 to 2013 that finally 22 full text articles including 4 Persian and 18 English were reviewed and evaluated.
Results: The literature review suggests a strong possible association between maternal serum leptin levels and maternal weight gain during pregnancy, and this relation was a significant correlation in most studies independent of body mass index.
Conclusion: Although the results of this review article indicate a strong association between maternal serum leptin and their weight gain during pregnancy, but due to controversial studies in this field, further studies are needed for definite judgment


  1. De Assis S, Wang M, Goel S, Foxworth A, Helferich W, Hilakivi-Clarke L. Excessive Weight Gain during Pregnancy Increases Carcinogen-Induced Mammary Tumorigenesis in Sprague-Dawley and Lean and Obese Zucker Rats. J Nutr 2006;136(4):998-1004.
  2. Khosrobeigi A KM, Ahmadvand H, Nasimidoost M. Comparison of serum levels of leptin and adiponectin in women Pregnant women with gestational diabetes and healthy. Iran journal of gynecology and infertility 2013 ;16(84):1-9. (Persian).
  3. Mazaki-Tovi S1, Kasher-Meron M, Hemi R, Haas J, Gat I, Lantsberg D, et al. Chemerin is present in human cord blood and is positively correlated with birthweight. Am J Obstet Gynecol 2012 ;207(5):412.e1-10
  4. Wendremaire M1, Bardou M, Peyronel C, Hadi T, Sagot P, Morrison JJ, et al. Effects of leptin on lipopolysaccharide-induced myometrial apoptosis in an in vitro human model of chorioamnionitis. Am J Obstet Gynecol 2011 ;205(4):363.e1–e9.
  5. Butte NF, Hopkinson JM, Nicolson MA.. Hopkinson, Nicolson MA. Leptin in Human Reproduction: Serum Leptin Levels in Pregnant and Lactating Women. J Clin Endocrinol Metab 1997;82(2):585-9.
  6. Jaime Hennessey, Dobson A. Leptin As Fat Orchestrator. Reviews in Undergraduate Research. 2003; 2:8-12.
  7. Yanni D1, Darendeliler F, Bas F, Kucukemre Aydin B, Coban A, Ince Z. The role of leptin, soluble leptin receptor, adiponectin and visfatin in insulin sensitivity in preterm born children in prepubertal ages. Cytokine. 2013; 64(1):448-53.
  8. Otero M, Lago R, Lago F, Casanueva FF, Dieguez C, Gómez-Reino JJ, et al. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 2005 ;579(2):295-301.
  9. Rodríguez L1, Panadero MI, Roglans N, Otero P, Alvarez-Millán JJ, Laguna JC, et al. Fructose during pregnancy affects maternal and fetal leptin signaling. The Journal of Nutritional Biochemistry 2013 ; 24(10):1709-16.
  10. Braun M, Young J, S. Reiner C, Poster D, P. Wüthrich R, AL S. Pregnancy in a Woman with a Leptin-Receptor Mutation. The New England Journal of Medicine. 2012; 15;366(11):1064-5.
  11. Coupé B, Grit I, Hulin P, Randuineau G, Parnet P. Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis. PLoS One 2012;7(1): e30616.
  12. Misra VK, Trudeau S. The influence of overweight and obesity on longitudinal trends in maternal serum leptin levels during pregnancy. Obesity (Silver Spring) 2011 ; 19(2):416-21.
  13. Lecke SB, Morsch DM, Spritzer PM. Leptin and adiponectin in the female life course. Braz J Med Biol Res 2011;44(5):381-7.
  14. Pérez-Pérez A1, Gambino Y, Maymó J, Goberna R, Fabiani F, Varone C , et al. MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells. Biochem Biophys Res Commun 2010 ;396(4):956-60.
  15. Akansu Saylik S, Alki I, Bayram N, Tuna V, Imamoglu N, Ceylan Y. Maternal serum leptin levels in severe preeclamptic pregnant women in early postpartum stage. International Journal of Obstetrics and Gynecology 2013;1(2):10-14.
  16. Nazarian A, Niknam F, Mazloomzadeh S, Kashanian M, Mazloomi S. Relationship between Chemerin and Metabolic syndrome in diabetic and non-diabetic pregnants.Endocrine and Metabolism of Iran Journal 2012;14(5):423-9. (Persian).
  17. Javad Heshmati, Namazi n. Leptin in pregnancy. Behbood 2010. (Persian).
  18. Walker CD, Naef L, d'Asti E, Long H, Xu Z, Moreau A, et al. Perinatal maternal fat intake affects metabolism and hippocampal function in the offspring: a potential role for leptin. Ann N Y Acad Sci 2008;1144:189-202. English.
  19. Michael C. Henson, Castracane VD. Leptin in Pregnancy: An Update. Biology of Reproduction 2006;74(2):218–29.
  20. Schmidt MI1, Duncan BB, Vigo A, Pankow JS, Couper D, Ballantyne CM, et al. Leptin and incident type 2 diabetes: risk or protection? Diabetologia. 2006; 49(9):2086-96.
  21. Jeffrey M. Friedman. The Function of Leptin in Nutrition, Weight, and Physiology. Nut Rev 2002 ; 60(10 Pt 2):S1-14.
  22. Grosfeld A, Turban S, André J, Cauzac M, Challier JC, Hauguel-de Mouzon S, et al. Transcriptional effect of hypoxia on placental leptin. FEBS Lett 2001; 502(3):122-6.
  23. Lea RG1, Howe D, Hannah LT, Bonneau O, Hunter L, Hoggard N.Hoggard. placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol Hum Reprod 2000;6(8):763-9.
  24. Pedro L. Prieto-Hontoria a, Patricia Pérez-Matute b, Marta Fernández-Galilea a, Matilde Bustos c, J. Alfredo Martínez a, Moreno-Aliaga MJ. Role of obesity-associated dysfunctional adipose tissue in cancer: A molecular nutrition approach. Biochimica et Biophysica Acta 2011; 1807(6):664-78.
  25. T Peter Stein, Theresa O Scholl , Margaret D Schluter, Schroeder CM. Plasma leptin influences gestational weight gain and postpartum weight retention. Am J Clin Nutr. 1998; 68(6):1236-40.
  26. Schwartz GJ, Azzara AV, Heaner MK. Roles for central leptin receptors in the control of meal size. Appetite 2013; 71:466-9.
  27. Smucny J, Cornier MA, Eichman LC, Thomas EA, Bechtell JL, Tregellas JR. Brain structure predicts risk for obesity Appetite 2012; 59(3):859–65.
  28. Tessiera, Z.M. Ferraroc, Gruslinb. Role of leptin in pregnancy: Consequences of maternal obesity. Placenta  2013; 34(3):205-11.
  29. Martin G. Myers, Michael A. Cowley, unzberg HM. Mechanisms of Leptin Action and Leptin Resistance. The Annual Review of Physiology 2008; 70:537-56.
  30. Maymó JL, Pérez Pérez A, Gambino Y, Calvo JC, Sánchez-Margalet V, Varone CL. Review: Leptin gene expression in the placenta – Regulation of a key hormone in trophoblast proliferation and survival. Placenta 2011;32(2):S146–53.
  31. Gambino YP1, Maymó JLPérez Pérez ACalvo JCSánchez-Margalet VVarone CL. Elsevier Trophoblast Research Award Lecture: Molecular mechanisms underlying estrogen functions in trophoblastic cells − Focus on leptin expression. Placenta 2012 ;33(2):S63–70.
  32. Nogueiras R, Seeley RJ. Our evolving understanding of the interaction between leptin and dopamine system to regulate ingestive behaviors. Mol Metab 2012  ;1(1-2):8-9.
  33. Maghbooli Zh, Hosinnezhad A, KhoshniyyatNikoo M, Arzaghi SM, Rahmani M, Larijani B. Leptin serum levels in gestational diabetes. Iran diabetes and Lipid journal 2006;1(18):57-66. (Persian).
  34. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Williams obstetrics, 23rd ed. McGraw Hill Professional 2010;23:15.(persian).
  35. Hogg KBlair JDvon Dadelszen PRobinson WP. Hypomethylation of the LEP gene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia. Mol Cell Endocrinol 2013 ;367(1-2):64–73.
  36. Fraser ATilling KMacdonald-Wallis CSattar NBrion MJBenfield L, et al. Association of Maternal Weight Gain in Pregnancy With Offspring Obesity and Metabolic and Vascular Traits in Childhood. Circulation 2010 ; 121(23):2557-64.
  37. Macêdo GSFerreira CLMenegaz AArantes VCVeloso RVCarneiro EM, et al. Correlation of serum leptin and insulin levels of pregnant protein-restricted rats with predictive obesity variables. Braz J Med Biol Res 2008 ;41(6):519-25.
  38. Group ECW. Nutrition and reproduction in women. Hum Reprod Update. 2006 ;12(3):193-207. 
  39. SCHUBRING C, KIESS W, Englaro P, RASCHER W, Dotsch J, HANITSCH S, et al. Levels of Leptin in Maternal Serum, Amniotic Fluid, and Arterial and Venous Cord Blood: Relation to Neonatal and Placental Weight. Journal of Clinical Endocrinology and Metabolism 1997;82(5):1480-3.
  40. Rashidi B, Haghollahi F, Tehranian N, Shariat M, Zayeri F, Bagheri M, et al. Effect of calcium-vitamin D treatment in infertile women with polycystic ovary syndrome. Journal of Reproduction and Infertility 2005:225-33. (Persian).
  41. Gungor SGurates BAydin SSahin IKavak SBKumru S, et al. Ghrelins, obestatin, nesfatin-1 and leptin levels in pregnant women with and without hyperemesis gravidarum. Clin Biochem 2013 ;46(9):828-30.
  42. Higgins MFRussell NMBrazil DPFirth RGMcAuliffe FM.. Fetal and maternal leptin in pre-gestational diabetic pregnancy. Int J Gynaecol Obstet 2013;120(2):169–72
  43. Sánchez JPriego TGarcía APLlopis MPalou MPicó C, et al. Maternal supplementation with an excess of different fat sources during pregnancy and lactation differentially affects feeding behavior in offspring: putative role of the leptin system. Mol Nutr Food Res  2012 ;56(11):1715-28
  44. Chen ZZhao YYang YLi Z. Leptin withdrawal after birth: A neglected factor account for cognitive deficit in offspring of GDM mother. Med Hypotheses 2011;77(1):125-7
  45. Mojgan Mokhtari, Mohammad Hashemi, Minoo Yaghmaei, Mohammad Naderi, Abdolsamad Shikhzadeh, Ghavami S. Evaluation of the serum leptin in normal pregnancy and gestational diabetes mellitus in Zahedan, southeast Iran. Arch Gynecol Obstet 2011;284(3):539-42
  46. Horosz E1, Bomba-Opon DASzymanska MWielgos M. Third trimester plasma adiponectin and leptin in gestational diabetes and normal pregnancies. Diabetes Res Clin Pract  2011;93(3):350-6.
  47. Dabiri Oskooyi A, Mazloomzadeh S, Amir Moghaddami H, Akbarshahi E. Comparing serum leptin levels in preeclampcia and normotensive pregnants, referring to Valie-asr(aj) educational treatment center in Zanjan in 1385. Scientific Research Journal of Zanjan University of Medical Sciences 2011;19(77):7-70. (Persian).
  48. Genova M, Todorova K, Tzatchev K. LEVEL OF LEPTIN IN PREGNANT WOMEN WITH RISK FOR DIABETES. 18 th Meeting of Balkan Clinical Laboratory Federation. Tirana; 2010.
  49. Savino FLiguori SALupica MM. Adipokines in breast milk and preterm infants. Early Hum Dev 2010 ;86( Suppl 1):77-80.
  50. Ludwig DS1, Currie J. The association between pregnancy weight gain and birthweight: a within-family comparison. Lancet  2010;376(9745):984-90
  51. Wolff SLegarth JVangsgaard KToubro SAstrup A. A randomized trial of the effects of dietary counseling on gestational weight gain and glucose metabolism in obese pregnant women. Int J Obes (Lond)  2008 ;32(3):495-501
  52. Mumtaz F1, Memon ARYousfani STahir SMKhushk I,  Memon M, et al. Role of serum Leptin level as a marker of severity of pre eclampsia. J Ayub Med Coll Abbottabad 2008 ;20(1):13-5.
  53. Verhaeghe J, Van Bree R, E. VH. Maternal body size and birth weight: can insulin or adipokines do better?. Metabolism 2006 ;55(3):339-44.
  54. Villamor ECnattingius S.. Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. Lancet 2006 ;368(9542):1164-70.
  55. Martínez-Abundis EGonzález-Ortiz MPascoe-González S. Serum leptin levels and the severity of preeclampsia. Arch Gynecol Obstet 2000 ;264(2):71-3.
  56. Kim KHKim YJLee SOh SWLee KPark Y, et al. Evaluation of plasma leptin levels & BMI as predictor of postpartum weight retention. Indian J Med Res 2008 ;128(5):595-600
  57. Helland IBReseland JESaugstad ODDrevon CA. Leptin Levels in Pregnant Women and Newborn Infants: Gender Differences and Reduction During the Neonatal Period. Pediatrics 1998;101(3):E12.
  58. Hendler IBlackwell SCMehta SHWhitty JERussell ESorokin Yet al.. The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia. Am J Obstet Gynecol 2005;193(3 Pt 2):979-83.
  59. Pimentel GD, Ropelle ER, Rochaa GZ, Carvalheira JBC. The role of neuronal AMPK as a mediator of nutritional regulation of food intake and energy homeostasis. Metabolism 2013;62(2):171-8.
  60. Wuntakal RKaler MHollingworth T. Women with high BMI: should they be managed differently due to antagonising action of leptin in labour?. Med Hypotheses 2013;80(6): 767-8.
  61. Amjadi FS, Salehi E, Javanmard SH. leptin role in fertility. Journal of Isfahan Medical School 2011 ;28(121):1701-11. (Persian).
  62. Brynhildsen JSydsjö GBlomberg MClaesson IMTheodorsson ENyström F, et al. Leptin and adiponectin in cord blood from children of normal weight, overweight and obese mothers. Acta Paediatr  2013 ;102(6):620-4