Evaluation of Neurohormones in sleep pattern of patients with polycystic ovary syndrome

Document Type : Original Article


1 Assistant Professor, Vali-e-Asr Reproductive Health Research Center, Vali-e-Asr Hospital, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

2 Lecture, Department of Community Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.

3 Assistant Professor, Department of Pathology, School of Medicine, Pathology laboratory of Vali-e-Asr Hospital, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

4 M.Sc. of Midwifery, Vali-e-Asr Reproductive Health Research Center, Vali-e-Asr Hospital, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.


Introduction: Human spends approximately one third of their live in sleeping, but still the function of this behavior is not well understood. This study was performed with the aim to evaluate the double role of sleep and hormonal process of two axis of hypothalamus-pituitary-adrenal and gonadal in patients with polycystic ovary syndrome (PCO).
Methods: this case-control study was performed on 77 patients with PCO in Vali-e-Asr Reproductive Health Research Center of Imam Khomeini Hospital at 2012. In this study, serum levels of stress neurohormones, beta-endorphin, progesterone and sleep were evaluated in 77 patients with polycystic ovarian syndrome and 97 healthy women. Sleep patterns were evaluated in two groups by the questionnaire of Pittsburgh Sleep Quality Index PSQI. Analysis of data was performed using statistical software SPSS (version 18) and chi-square, Kolmogorov-Smirnov test, Mann-Whitney, Pearson, Spearman and regression analysis. PResults: Serum levels of stress hormones of adrenaline and noradrenaline in the PCO group who sleep earlier (3.88 ± 2.54) was significantly lower than those in the same group who sleep later (6.43 ± 4.71 (P=0.041). Level of beta-endorphin (P=0.001), and melatonin in the PCO group was lower than the control group. Regression analysis showed that in patients group, only cortisol levels showed a significant relationship with sleep quality scores (P=0.023).
Conclusion: the neurohormonal levels of Adrenaline, Noradrenaline, Melatonin and Betaendorphine are significantly reduced in the patients who sleep late at night and wake up late in the morning.


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