Maternal and neonatal outcome of women with twin pregnancy co-existing a molar pregnancy and a normal fetus: a systematic review and Meta-Analysis

Document Type : Original Article

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Tabriz University of Medical Sciences, Al-Zahra Hospital, Tabriz, Iran.

2 Associate Professor, Department of Physiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

4 Resident, Department of Obstetrics and Gynecology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Introduction: Molar pregnancy along with a live fetus is not rare, and survival rate of the live fetus with mole is variable and dependent on mole fraction effects. The effects of molar pregnancy for mother include preeclampsia, bleeding, thyroid disorders, and persistent gestational trophoblastic disease. This study was performed with the aim to investigate the maternal and fetal effects of Molar pregnancy along with a live fetus in order to facilitate deciding about termination of pregnancy in spite of the presence of a live fetus or continue it accepting all future potential effects.
Methods: to access the articles, all the articles published on this topic between 1980 and 2012 were extracted using a systematic search in Embase, Google scholar, science direct, Iranmedex, PubMed, SID, Magiran, medlib, irandoc and Medline databases, and after evaluation, finally, data of 29 articles was analyzed using the statistical software CMA2.
Results: The results of the statistical analysis indicated that the rate of the birth of the live fetus (event rate: 0.204) is greater than the persistent gestational trophoblastic disease (event rate: 0.186). The event rate of bleeding was 0.258 and event rate of preeclampsia was 0.211.
Conclusion: In this study, the birth rate of the live fetus was greater than the persistent gestational trophoblastic disease. Bleeding was the most complication and then, preeclampsia had the highest prevalence.

Keywords

References

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