Association of asymptomatic bacteriuria and preeclampsia in pregnant women

Document Type : Original Article

Authors

1 Assistant Professor, Department of Obstetrics and Gynecology , Semnan University of Medical Sciences, Semnan, Iran.

2 Associate Professor, Research center of social factors effective on health, Department of Social Medicine, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

3 Medical Student, Student Research Committee, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Abstract

Introduction: Preeclampsia is one of the major causes of maternal mortality and also from the important causes of major fetal, neonatal, and maternal complications. Different studies have mentioned that infections during pregnancy are possible pathophysiology of preeclampsia. This study was performed with the aim to evaluate the association of asymptomatic bacteriuria (ASB (and preeclampsia in pregnant women.
Methods: This cross-sectional study was performed in 2012 on 320 pregnant women referred to Amiralmomenin and Shafa hospitals of Semnan. 160 pregnant women who presented preeclampsia after 20 weeks of gestational age were selected as case group and 160 healthy pregnant women at the same gestational age as control group. Data were analyzed using SPSS software (version 16), t-test, and Chi-square test. PResults: The prevalence of ASB was 13.8% (22 cases) in case group and 5.6% (9 cases) in control group. The association between preeclampsia and asymptomatic bacteriuria was significant in pregnant women (P=0.027), so that, the possibility of asymptomatic bacteriuria in women with preeclampsia was 2.59 times of control group.
Conclusion: Asymptomatic bacteriuria is a factor effective on preeclampsia, therefore, screening of asymptomatic bacteriuria on prenatal care are recommended.

Keywords


  1. Robillard PY, Dekker G, Chaouat G, Hulsey TC. Etiology of preeclampsia: maternal vascular predisposition and couple disease--mutual exclusion or complementarity? J Reprod Immunol 2007; 76: 1-7.
  2. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371: 75-84.
  3. Eiland E, Nzerue C, Faulkner M. Preeclampsia 2012. J Pregnancy 2012; 2012: 586578.
  4. Cunningham F, Leveno K, Bloom S, Hauth J, Gilstrap III L. Williams Obstetrics. New York: McGraw-Hill; 2005.
  5. Al-Jameil N, Aziz Khan F, Fareed Khan M, Tabassum H. A Brief Overview of Preeclampsia. J Clin Med Res 2014; 6: 1-7.
  6. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005; 308: 1592-4.
  7. Herrera JA, Chaudhuri G, Lopez-Jaramillo P. Is infection a major risk factor for preeclampsia? Med Hypotheses 2001; 57: 393-7.
  8. von Dadelszen P, Magee LA. Could an infectious trigger explain the differential maternal response to the shared placental pathology of preeclampsia and normotensive intrauterine growth restriction? Acta Obstet Gynecol Scand 2002; 81: 642-8.
  9. Haggerty CL, Klebanoff MA, Panum I, Uldum SA, Bass DC, Olsen J, et al. Prenatal infection increases the risk of preeclampsia. Pregnancy Hypertens 2013; 3: 151-4.
  10. Gurbuz A, Karateke A, Mengulluoglu M, Gedikbasi A, Ozturkmen M, Kabaca C, et al. Can serum HCG values be used in the differential diagnosis of pregnancy complicated by hypertension? Hypertens Pregnancy 2004; 23: 1-12.
  11. Kumar A, Begum N, Prasad S, Lamba AK, Verma M, Agarwal S, et al. Role of cytokines in development of pre-eclampsia associated with periodontal disease - Cohort Study. J Clin Periodontol  2014; 41: 357-65
  12. Saghafi N, Hoseini A, Amel S, Ghazanfari M, Namani H. Comparison of Serum Heat-Shock Protein 70 Levels in Pre-Eclampsia with Normal Pregnancy. Iranian Journal of Obstetrics Gynecology and Infertility  2013; 16 (70): 1-8
  13. Nicolle LE. Asymptomatic bacteriuria. Curr Opin Infect Dis 2014; 27: 90-6.
  14. Sheikh M, Khan M, Khatoon A, Arain G. Incidence of urinary tract infection during pregnancy. Eastern Mediterranean health journal 2000; 6: 265-71.
  15. Wing DA, Fassett MJ, Getahun D. Acute pyelonephritis in pregnancy: an 18-year retrospective analysis. Am J Obstet Gynecol 2013.
  16. Hill JA, Devoe LD, Bryans CI, Jr. Frequency of asymptomatic bacteriuria in preeclampsia. Obstet Gynecol 1986; 67: 529-32.
  17. Schieve LA, Handler A, Hershow R, Persky V, Davis F. Urinary tract infection during pregnancy: its association with maternal morbidity and perinatal outcome. Am J Public Health 1994; 84: 405-10.
  18. Conde-Agudelo A, Villar J, Lindheimer M. Maternal infection and risk of preeclampsia: systematic review and metaanalysis. Am J Obstet Gynecol 2008; 198: 7-22.
  19. Bryant RE, Windom RE, Vineyard JP, Jr., Sanford JP. Asymptomatic Bacteriuria in Pregnancy and Its Association with Prematurity. J Lab Clin Med 1964; 63: 224-31.
  20. Low JA, Johnston EE, McBride RL, Tuffnell PG. The Significance of Asymptomatic Bacteriuria in the Normal Obstetric Patient. Am J Obstet Gynecol 1964; 90: 897-906.
  21. Qureshi RN, Khan KS, Darr O, Khattak N, Farooqui BJ, Rizvi JH. Bacteriuria and pregnancy outcome: a prospective hospital-based study in Pakistani women. J Pak Med Assoc 1994; 44: 12-3.
  22. Chrisoulidou A, Goulis DG, Iliadou PK, Dave JR, Bili H, Simms C, et al. Acute and chronic Chlamydia pneumoniae infection in pregnancy complicated with preeclampsia. Hypertens Pregnancy 2011; 30: 164-8.
  23. Banhidy F, Acs N, Puho EH, Czeizel AE. Pregnancy complications and birth outcomes of pregnant women with urinary tract infections and related drug treatments. Scand J Infect Dis 2007; 39: 390-7.
  24. Kincaid-Smith P, Bullen M. Bacteriuria in Pregnancy. Lancet 1965; 1: 395-9.
  25. Fischer W, Lamm D, Bayer H, Birnbaum M. [Correlation between urinary tract infection and pregnancy toxemias]. Zentralbl Gynakol  1970; 92: 1326-33.
  26. Drazancic A, Balasa A, Zadjelovic J, Kralj-Pejakovic L. (The effect of treatment of bacteriuria on pregnancy outcome). Jugosl Ginekol Perinatol 1989; 29: 15-8.
  27. Whalley PJ, Martin FG, Peters PC. Significance of Asymptomatic Bacteriuria Detected during Pregnancy. JAMA 1965; 193: 879-81.
  28. Smaill F, Vazquez JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev 2007: CD000490.