Comparison of serum vitamin D levels in pregnant women with preeclampsia with healthy pregnant women

Document Type : Original Article

Authors

1 Assistant Professor, Department of Obstetrics and Gynecology, School of Medicine , Kurdistan University of Medical Sciences , Sanandaj, Iran.

2 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine , Kurdistan University of Medical Sciences , Sanandaj, Iran.

3 Resident of Obstetrics and Gynecology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Abstract

Introduction: Preeclampsia is a pregnancy-specific syndrome that has two stages, the first stage occurs before 20 weeks of gestation before the onset of clinical symptoms. The second stage includes the incidence of clinical symptoms. one of the causes of its incidence is vitamin D deficiency. This study was performed with the aim to evaluate the relationship between serum level of vitamin D and preeclampsia in pregnant women.
Methods: This case - control study was done on 50 pregnant women with severe preeclampsia and gestational age below 34 weeks and 100 non-preeclampsia pregnant women to delivery department of Besat Hospital in 2011.Data collection tool in this study was a questionnaire that was designed based on the variables. Blood sample was taken from all the research units to measure level of vitamin D. Maternal serum levels of 25-hydroxyvitamin D was measured by radio immunoassay method. in the laboratory. Data analysis was performed using SPSS software (version 18), Chi-square, Fisher exact, Independent t, and Kolmogorov-Smirnov tests.
Results: Vitamin D deficiency  was observed in 80% of cases and 75% of controls. The mean of 25-hydroxyvitamin D in the case  group was 11.0 ± 9.4 (ml / ng) and in control group was 16.3 ± 10.0, which had statistically significant difference (p=0.003).
Conclusion: vitamin D level of most pregnant women was lower than normal. According to the findings of this study, D deficiency can be considered as a risk factor for preeclampsia. Although, more cohort studies are needed to confirm this.

Keywords

References

  1. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DL, Spong CY. Williams obstetrics. 23rd ed. New York:MaGrawHill;2010.
  2. Powe CE, Seely EW, Rana S, Bhan I, Ecker J, Karumanchi SA, et al. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension 2010 Oct;56(4):758-63.
  3. Sabour H, Hossein-Nezhad A, Maghbooli Z, Madani F, Mir E, Larijani B. Relationship between pregnancy outcomes and maternal vitamin D and calcium intake: A crosssectional study. Gynecol Endocrinol 2006 Oct;22(10):585-9.
  4. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD. Plasma 25- hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol 2010 Oct;203(4):366.e1-6.
  5. Eskenazi B, Fenster L, Sidney S. A multivariate analysis of risk factors for preeclampsia. JAMA 1991 Jul 10;266(2):237-41.
  6. MacKay AP, Berg CJ, Atrash HK. Pregnancy-related mortality from preeclampsia and eclampsia. Obstet Gynecol 2001 Apr;97(4):533-8.
  7. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007 Sep;92(9):3517-22.
  8. Shand AW, Nassar N, Von Dadelszen P, Innis SM, Green TJ. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for preeclampsia. BJOG 2010 Dec;117(13):1593-8.
  9. Maghbooli Z, Hosseinnezhad A, Shafaei AR, Karimi F, Madani FS, Larijani B. Vitamin D status in pregnant women and their newborns in Iran. BMC Pregnancy Childbirth 2007 Feb 12;7:1.
  10. Robinson CJ, Wagner CL, Hollis BW, Baatz JE, Johnson DD. Maternal vitamin D and fetal growth in early-onset severe preeclampsia. Am J Obstet Gynecol 2011 Jun;204(6):556.e1-4.
  11. Fischer D, Schroer A, Lüdders D, Cordes T, Bücker B, Reichrath J, et al. Metabolism of vitamin D3 in the placental tissue of normal and preeclampsia complicated pregnancies and premature births. Clin Exp Obstet Gynecol 2007;34(2):80-4.
  12. Hoffman B, Horsager R, Roberts S, Rogers V, Santiago-Muoz P, Worley K. Williams obstetrics: study guide. 23rd ed. New York:McGraw-Hill;2007.
  13. Amirali Akbari S, Dolatian M, Valaei N. [Prevalence of preeclampsia, eclampsia and their related factors in women referring to medical university hospital in Tehran, 2001] [Article in Persian]. Pajohandeh J 2004;9(40):225-30.
  14. Piree Sh, Kiani Asiabar A, Faghihzadeh S. [Prevalence of pre-eclampsia, eclampsia, and the impact of demographic factors on] [Article in persian[. Daneshvar J 2001;8(32):35-42.
  15. Safari M, Yazdanpanah B. [The incidence of preeclampsia and fetal and maternal complications in women referring to Imam Sajjad Houspital, Yasuj, 2001] [Article in Persian]. J Sharekord Univ Med Sci 2003 Summer;5(2):47-53.

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