Comparison of serum vitamin D levels in pregnant women with preeclampsia with healthy pregnant women

Document Type : Original Article


1 Assistant Professor, Department of Obstetrics and Gynecology, School of Medicine , Kurdistan University of Medical Sciences , Sanandaj, Iran.

2 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine , Kurdistan University of Medical Sciences , Sanandaj, Iran.

3 Resident of Obstetrics and Gynecology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.


Introduction: Preeclampsia is a pregnancy-specific syndrome that has two stages, the first stage occurs before 20 weeks of gestation before the onset of clinical symptoms. The second stage includes the incidence of clinical symptoms. one of the causes of its incidence is vitamin D deficiency. This study was performed with the aim to evaluate the relationship between serum level of vitamin D and preeclampsia in pregnant women.
Methods: This case - control study was done on 50 pregnant women with severe preeclampsia and gestational age below 34 weeks and 100 non-preeclampsia pregnant women to delivery department of Besat Hospital in 2011.Data collection tool in this study was a questionnaire that was designed based on the variables. Blood sample was taken from all the research units to measure level of vitamin D. Maternal serum levels of 25-hydroxyvitamin D was measured by radio immunoassay method. in the laboratory. Data analysis was performed using SPSS software (version 18), Chi-square, Fisher exact, Independent t, and Kolmogorov-Smirnov tests.
Results: Vitamin D deficiency  was observed in 80% of cases and 75% of controls. The mean of 25-hydroxyvitamin D in the case  group was 11.0 ± 9.4 (ml / ng) and in control group was 16.3 ± 10.0, which had statistically significant difference (p=0.003).
Conclusion: vitamin D level of most pregnant women was lower than normal. According to the findings of this study, D deficiency can be considered as a risk factor for preeclampsia. Although, more cohort studies are needed to confirm this.


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