Primary non-Hodgkin ovarian lymphoma: a case report

Document Type : Case report

Authors

1 Associate Professor, Department of Radiation Oncology, Cancer Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Resident of Radiation of Oncology, Cancer Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Professor, Department of Obstetrics and Gynecology, Ovulation Disorders Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Associate professor, Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Assistant professor, Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

6 Resident of Radiation Oncology, Cancer Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: Primary ovarian non- Hodgkin lymphoma especially T-cell type is a very rare disease which is classified in the group of malignant small round cell tumors. In these tumors, for detection of primary tumor type, it is very crucial to perform more evaluation of the patient and disease, and also using of further pathologic cytologic methods such as immunohistochemistry, immunophenotyping by flow cytometry, RT-PCR (reverse transcriptase- polymerase chain reaction), FISH (flurescent in situ hybridization), electron microscopic approach and molecular genetics methods. This study was performed with the aim to demonstrate the importance of complement evaluations in patients with diagnosis of malignant small round cell tumor of ovary.
Case report: In our report, a 31-years old woman with complaint of abdominal pain and diagnosis of ovarian mass has been evaluated. During evaluation process, she had several primary diagnosis, but eventually, with complement evaluation of immunohistochemistry, the final diagnosis of ovarian T-cell lymphoma was confirmed and based on it, treatment was performed.
Conclusion: Malignant small round cell tumors in ovary need to several complement pathologic evaluations for confirmingofdefinitive diagnosis and planning of correct treatment.

Keywords

References

  1. Kocjan G. Fine needle aspiration cytology: diagnostic principles and dilemmas. Berlin:Springer;2006.
  2. Akhtar M, Iqbal MA, Mourad W, Ali MA. Fineneedle aspiration biopsy diagnosis of small round cell tumors of childhood : a comprehensive approach. Diagn Cytopathol 1999 Aug;21(12):81-91.
  3. Akhtar M, Ali MA, Sabbah R, Bakry M, Nash JE. Fine-needle aspiration biopsy diagnosis of round cell malignant tumors of childhood. A combined light and electron microscopic approach. Cancer 1985 Apr 15;55(8):1805-17.
  4. Brahmi U, Rajwanshi A, Joshi K, Dey P, Vohra H, Ganguly NK, et al. Flow cytometric immunophenotyping and comparison with immunocytochemistry in small round cell tumors. Anal Quant Cytol Histol 2001 Dec;23(6):405-12.
  5. Leon ME, Hou JS, Galindo LM, Garcia FU. Fineneedle aspiration of adult small round cell tumors studied with flow cytometry. Diagn cytopathol 2004 Sep;31(3):147-54.
  6. Sigstad E, Dong HP, Devidson B, Berner A, Tierens A, Risberg B. The role of flow cytometric immunophenotyping in improving the diagnostic accurancy in referred fin-needle aspiration specimen. Diagn Cytopathol 2004 Sep;31(3):159-63.
  7. Chorlton I, Norris HJ, King FM. Malignant reticuloendothelial disease involving the ovary as a primary manifestation: a series of 19 lymphoma and 1 granulocytic sarcoma. Cancer 1974 Aug;34(2):397-407.
  8. Vang R, Medeiros LJ, Fuller GN, Sarris AH, Deavers M. Non-Hodgkin's lymphoma involving the gynecologic tract: a review of 88 cases. Adv Anat Pathol 2001 Jul;8(4):200-17.
  9. Edge SB, Byrd DR, Compton CC. Lymphoid neoplasm. 7th ed. New York:springer;2010.
  10. Dickersin GR, Kline IW, Scully RE. Small cell carcinoma of the ovary with hypercalcemia: a report of eleven cases. Cancer 1982 Jan 1;49(1):188-97.
  11. Clement PB. Selected miscellaneous lesion: small cell carcinoma, mesothelial lesion, mesenchymal and mixed neoplasm, and non-neoplastic lesions. Mod Pathol 2005 Feb;18 Suppl 2:S113-29.
  12. Barodeau J, Rodgers M , Braun L, Azarow K, Forouhar M, Faucette M. Small cell carcinoma: a rare, aggressive tumor masquerading as constipation in a teenager with a fatal outcome. J Pediatr Hematol Oncol 2010 May;32(4):e139-41.
  13. Young RH, Oliver E , Sculty RE. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J Surg Pathol 1994 Nov;18(11):1102-16.
  14. Tahmasebi M, Cina M. Bilateral endometreal stromal sarcoma originating from ovarian endometriosis: a case report. Iran J Radiol 2009;6:33-6.
  15. Dal Y, Shen K, Lang H, Haung HF, Pan LY, Wu M, et al. Primary sarcoma of the ovary clinicopathological characteristics, prognostic factors and evaluation of therapy. Chin med J (Engl) 2011 May;124(9):1316-21.
  16. Quirk JT, Natarajan N. Ovarian cancer incidence in the united states, 1992-1999. Gynecol Oncol 2005 May;97(2):519-23.
  17. Schumer ST, Canistra SA. Granulosa cell tumor of the ovary. J Clin Oncol 2003 Mar 15;21(6)1180-9.
  18. Lawlor ER, Murphy JI, Sorensen PH, Fryer CJ. Metastatic primitive neuroectodermal tumor of the ovary: successful treatment with megadose chemotherapy followed by peripheral blood progenitor cell rescue. Med Pediatr Oncol 1997 Oct;29(4):308-12.
  19. Enzinger FM, Weiss SW. Primitive neuroectodermal tumor and related lesions. In: Enzinger FM, Weiss SW. Soft tissue tumors.3rd St. Louis:Mosby;1995:929-64.
  20. Gupta D, Deavers MT, Silva EG, Malpica A. Malignant melanoma involving the ovary: a clinicopathologic and immunohistochemical study of 23 cases. Am J Surg Pathol 2004 Jun;28(6):771-80.

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