Maternal outcomes caused by receiving magnesium sulfate to suppress preterm labor

Document Type : Original Article


1 Assistant Professor, Department of Midwifery, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

2 M.Sc. of Midwifery, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Assistant Professor, Department of Physiology, Women's Reproductive Health Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

4 Professor, Department of Obstetrics and Gynecology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.


Introduction: Nowadays, a high percentage of pregnant women experience preterm labor. This causes a lot of problems for mother and her premature infant. Women who experience preterm labor are usually treated with a certain drug compounds to prevent uterine contractions. This study was performed aimed to compare the effects of magnesium sulfate and nifedipine on inhibition of preterm labor and maternal complications caused by administration of magnesium sulfate and nifedipine.
Methods: This Interventional control trial study was performed on 80 pregnant women referring to Tabriz medical-training centers of Taleghani and Alzahra in 2012. One group was given sulfate magnesium and simultaneously received a placebo instead of nifedipine. The other group was given Nifedipine tablet and simultaneously, serum ringer was infused as placebo. Data collection tools consisted of checklist and patrograph form. Data was analyzed using SPSS software (version 15), and t-independent, chi-square, test, and Kolmogorov-Smirnov tests. PResults: Uterine contractions and labor progress was suppressed in 35 cases (87.5%) of Nifedipine group and 19 (47.5%) of sulfate magnesium group (P=?). Maternal tachycardia was observed in 27 cases (67.5%) of Nifedipine group and dyspnea in 26 (65%) of sulfate magnesium group. After delivery, no complication was observed in Nifedipine group, but 3 cases of uterine atony and 2 cases of the placenta abruption was occurred in sulfate magnesium group (P=?). Two groups were not significantly different in terms of delivery mode (P=0.7).
Conclusion: Nifedipine is more effective than sulfate magnesium to suppress preterm labor and has less side effects. Therefore, Nifedipine can be a better alternative in the treatment of preterm labor.


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