The Effect of Phenytoin Cream on Cesarean Wound Healing

Document Type : Original Article

Authors

1 Lecturer of Midwifery, School of Nursing and Midwifery, Islamic Azad University of Ahvaz Branch, Ahvaz, Iran.

2 Lecturer of Midwifery, School of Nursing and Midwifery, Islamic Azad University of Masjed Soleyman Branch, Masjed Soleyman, Iran.

3 Lecturer of Midwifery, Shushtar School of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Introduction: Cesarean is one of the most common surgical procedures in obstetrics and gynecology. Poor wound healing and failure of incision are the main causes of complications after cesarean delivery. The aim of the present study was to determine the effect of phenytoin cream on cesarean wound healing.
Methods: This double blind randomized clinical trial was conducted in 2012 on 80 candidate mothers for cesarean section in Imam Khomeini hospital of Ahvaz, Iran. Subjects were randomly divided into two phenytoin and placebo groups (n=40 for each). Cesarean wound healing was assessed using REEDA scale at days 7 and 14 after repair. Data were analyzed using SPSS software version 16 and independent t-tests, chi-square and Mann-Whitney tests. P value less than 0.05 was considered significant.
Results: The mean scores of wound healing in phenytoin group were significantly lower than placebo group at days 7 and 14 after delivery (p=0.001). There was a significant difference in total wound healing between two groups at day 14 after delivery (p=0.003).
Conclusion: Phenytoin cream has a significant effect on faster cesarean wound healing

Keywords

References

  1. Goharian V,Mogharehabed L. [Causes cesarean prevalence in Central Province] [Article in Persian]. J Arak Univ Med Sci1997;2(5):28-30.
  2. Afshar T, Amini N, Moghadam yegane J, Mardi A. [The cesarean section rate and indications in social security hospitals of Ardebil] [Article in Persian]. J Arak Univ Med Sci 2003;2(8):28-32.
  3. Cunningham FG, Leveno KJ, Bloom SL, HauthJC, Rouse DJ, Spong CY. Williams obstetrics. 23rd ed. New York:McGraw-Hill;2010:673.
  4. Najmi RS, Rehan N. Prevalence and determinants of caesarean section in a teaching hospital of Pakistan. J Obstet Gynaecol 2000 Sep;20(5):479-83.
  5. Ministry of Health and Medical Education. The Fertility Assessment Program Family Health Section. Tehran:Ministry of Health and Medical Education;2005.
  6. Naumann RW, Hauth JC, Owen J, Hodgkins PM, Lincoln T. Subcutaneous tissue approximation in relation towound disruption after cesarean delivery in obese women. Obstet Gynecol 1995 Mar;85(3):412-6.
  7. Magann EF, Chauhan SP, Rodts-palenik S, Bufkin L,Martin JN, Morrison JC. Subcutaneous stitch closure versus subcutaneous drain to prevent wound disruption after cesarean delivery: a randomized clinical trial. Am J Obstet Gynecol 2002 Jun;186(6):1119-23.
  8. Kores S, Vyavaharkar M, Akolekar R, Toke A, AmbiyyeV. Comparison of closure of subcutaneous tissue versus non-closure in relation to wound disruption after abdominal hysterectomy in obese patients. J Postgrad Med 2000 Jan-Mar;46(1):26-8.
  9. Campos AC, Groth AK, Branco AB. Assessment and nutritional aspects of wound healing. Curr Opin Clin Nutr Metab Care 2008 May;11(3):281-8.
  10. Lipscomb GH, Ling FW. Wound healing, suture material and surgical instrumentation. In: Rock JA, Jones HW. Te Linde's operative gynecology. 9th ed. Philadelphia:Lippincott Williams and Wilkins;2003:233-51.
  11. Nichols DH, Clarke-Pearson DL. Gynecologic obstetric and related surgery. 2nd ed. New York:Mosby;2000.
  12. Steen M, Cooper K, Marchant P, Griffiths-Jones M, Walker J. A randomized controlled trial to compare the effectiveness of ice-packs and Epifoam with cooling maternity gel pads at alleviating postnatal perineal trauma. Midwifery 2000 Mar;16(1):48-55.
  13. Scheinfeld N. Phenytoin in cutaneous medicine: its uses, mechanisms and side effects. Dermatol Online J 2003 Aug;9(3):6.
  14. Shapiro M. Acceleration of gingival wound healing in non-epileptic patients receiving diphenylhydantoin sodium (dilantin, epanutin). Exp Med Surg 1958;16(1):41-53.
  15. Madaghegh S, Salehian B, Tavasoli M. [Use of phenytoin in healing of war and non-war wounds] [Article in Persian]. Int J Dematol 1989;28(5):347-50.
  16. Pamela D, Hill RN. Psychometric property of the reeda. J Nurs Midwifery 1990 May-Jun;35(3):162-5.
  17. Sehhati Shaffaie F, Rashidi Fakari F, Javadzadeh Y, Ghojazadeh M. [Effect of the phenytoin cream on episiotomy healing in primipara women] [Article in Persian]. J Shahid Sadoughi Univ Med Sci 2012;20(2):152- 8.
  18. Riahi S, Mofid M, Imani H, Asgari A, Ghoshoni H, Habibi M, et al. [Effect topical phenytoin on skin wound healing in rat] [Article in Persian]. J Anat Iran 2005;3(4):269-79.
  19. Shaw J, Hughes CM, Lagan KM, Bell PM. The clinical effect of topical phenytoin wound healing: a systematic review. Br J Dermatol 2007 Nov;157(5):997-1004.
  20. Ghapanshi J, Haghighi F, Dehpoor GH. [Effect wound healing in operation in gigivictomy] [Article in Persian]. J Dent Shiraz 1998;1(1):31-5.
  21. Shafer WG, Beatty RE, Davis WB. Effect of dilantin sodium on tensile strength of healing wounds. Proc Soc Exp Biol Med 1958 Jun;98(2):348-50.
  22. Oluwatosin OM, Olabanji JK, Oluwatosin OA, Tijani LA, Onyechi HU. A comparison of topical honey and phenytoin in the treatment of chronic ulcers. Afr J Med Sci 2000 Mar;29(1):31-4.
  23. Muthukumarasamy MG, Sivakumar G, Manoharan G. Topical phenytoin in diabetic foot ulcers. Diabetes Care 1991 Oct;14(10):909-11.
  24. Dill RE, Lacopino AM. Myofibroblasts in phenytoin-induced hyperplastic connective tissue in rat and in human gingival overgrowth. J Periodontal 1997 Apr;68(4):375-80.
  25. Song S, Cheng T. [The effect of systemic and local irradiation on wound macrophages and the repair promoting action of phenytoin sodium] [Article in Chinese]. Zhonghua Yi Xue Za Zhi 1997 Jan;77(1):54-7.
  26. Kelln E, Gorlin R. Healing qualitative of an epilepsy drug. Dental Prog 1961;1:126-9.
  27. Asadbegy M, Mirazi N, Vatanchian M. [Comparative study of lotus corniculatus L. hydroethanolic extract and phenytoin ointment effects on Rat skin wound healing: morphometrical and histopathological studies] [Article in Persian]. J Cell Tissue 2011 Autumn;2(3):213-23.

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