Investigating the Correlation between C-reactive protein and Preterm delivery

Document Type : Original Article

Authors

1 M.Sc. of Immunology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

2 Assistant Professor, Department of Community Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

3 Assistant Professor, Department of Immunology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract

Introduction: Preterm delivery is the most important cause of neonatal mortality and morbidity. Infections and chronic inflammation are one of the main causes of preterm delivery. C-reactive protein (CRP) is a marker of inflammation that is secreted by hepatic cells in response to inflammatory stimuli. We examined the association between c-reactive protein as a marker of inflammation in pregnant women and risk of preterm delivery
Methods: This prospective case-control study was conducted between 2011 and 2012 on 200 pregnant women who referred to gynecologists office in Shiraz, Iran. Subjects were divided into three groups: 63 pregnant women who delivered before week 30 of pregnancy, 30 pregnant women who delivered between weeks 30-37 and 107 controls who delivered at term. Serum CRP was evaluated by Immunoturbidimetry Assay method with photometric analyzer in all groups. Data were analyzed by SPSS software version 16 and ANOVA test. P value Results: CRP concentration among women with preterm delivery before 30 weeks of gestation were increased compared to the other two groups (p<0.05). Also significant difference in CRP concentrations were seen in women with preterm labor before 30 weeks of gestation compared to those who had delivery after 37 weeks (p<0.05).
Conclusion: Increased CRP concentration directly correlates with preterm birth and it seems that CRP can be helpful in identifying women at risk of preterm birth.

Keywords

References

  1. Coussons-Read ME, Lobel M, Carey JC, Kreither MO, D’Anna K, Argys L, et al. The occurrence of preterm delivery is linked to pregnancy-specific distress and elevated inflammatory markers across gestation. Brain, behavior, and immunity. 2012;26(4):650-9.
  2. Greco E, Gupta R, Syngelaki A, Poon LC, Nicolaides KH. First-trimester screening for spontaneous preterm delivery with maternal characteristics and cervical length. Fetal diagnosis and therapy. 2012;31(3):154-61.
  3. Agrawal V, Hirsch E, editors. Intrauterine infection and preterm labor. Seminars in Fetal and Neonatal Medicine; 2012: Elsevier.
  4. Hagberg H, Gressens P, Mallard C. Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults .Annals of neurology. 2012;71(4):444-57.
  5. Kim CJ, Romero R, Kusanovic JP, Yoo W, Dong Z, Topping V, et al. The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth .Modern Pathology. 2010;23(7):1000-11.
  6. Vrachnis N, Vitoratos N, Iliodromiti Z, Sifakis S, Deligeoroglou E, Creatsas G. Intrauterine inflammation and preterm delivery. Annals of the New York Academy of Sciences. 2010;1205(1):118-22.
  7. Wei S-Q, Fraser W ,Luo Z-C. Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: a systematic review. Obstetrics & Gynecology. 2010;116(2, Part 1):393-401.
  8. Pejcic A, Kesic L, Milasin J. C-reactive protein as a systemic marker of inflammation in periodontitis. European journal of clinical microbiology & infectious diseases. 2011;30(3):407-14.
  9. Langhorst J, Elsenbruch S, Koelzer J, Rueffer A, Michalsen A, Dobos GJ. Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices. The American journal of gastroenterology. 2008;103(1):162-9.
  10. Okemefuna AI, Nan R, Miller A, Gor J, Perkins SJ. Complement factor H binds at two independent sites to Creactive protein in acute phase concentrations. Journal of Biological Chemistry. 2010;285(2):1053-65.
  11. Eisenhardt SU, Habersberger J, Murphy A, Chen Y-C, Woollard KJ, Bassler N, et al. Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques. Circulation research. 2009;105(2):128-37.
  12. Madan JC, Davis JM, Craig WY, Collins M, Allan W, Quinn R, et al. Maternal obesity and markers of inflammation in pregnancy. Cytokine. 2009;47(1):61-4.
  13. Kasper DC, Mechtler TP, Reischer GH, Witt A, Langgartner M, Pollak A, et al. The bacterial load of< i> Ureaplasma parvum in amniotic fluid is correlated with an increased intrauterine inflammatory response. Diagnostic microbiology and infectious disease. 2010;67(2):117-21.
  14. Fortunato SJ, Menon R, Lombardi SJ. Role of tumor necrosis factor-α in the premature rupture of membranes and preterm labor pathways. American journal of obstetrics and gynecology. 2002;187(5.26-5511:)
  15. Köszegi T. Immunoluminometric detection of human procalcitonin. Journal of biochemical and biophysical methods. 2002;53(1):157-64.
  16. Torbe A, Czajka R. Proinflammatory cytokines and other indications of inflammation in cervico-vaginal secretions and preterm delivery. International Journal of Gynecology & Obstetrics. 2004;87(2):125-30.
  17. Janeway CA, Travers P, Walport M, Shlomchik M. Immunobiology: The Immune System in Health &. 2005.
  18. Mazor M, Kassis A, Horowitz S, Wiznitzer A, Kuperman O, Meril C, et al. Relationship between C-reactive protein levels and intraamniotic infection in women with preterm labor. The Journal of reproductive medicine. 1993;38(10):799-803.
  19. Wolf M, Kettyle E, Sandler L, Ecker JL, Roberts J, Thadhani R. Obesity and preeclampsia: the potential role of inflammation. Obstetrics & Gynecology. 2001;98(5):757-62.
  20. Hvilsom GB, Thorsen P, Jeune B, Bakketeig LS. C‐reactive protein: a serological marker for preterm delivery? Acta obstetricia et gynecologica Scandinavica. 2002;81(5):424-9.
  21. Halder A, Agarwal R, Sharma S, Agarwal S. Predictive significance of C reactive protein in spontaneous preterm delivery: a prospective cohort study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2013;2(1):47-51.
  22. Ghezzi F, Franchi M, Raio L, Di Naro E, Bossi G, D'Eril GVM, et al. Elevated amniotic fluid C-reactive protein at the time of genetic amniocentesis is a marker for preterm delivery. American journal of obstetrics and gynecology.73-268:(2)186,2002.
  23. Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. American journal of obstetrics and gynecology. 1999;180(2):499-506.
  24. Yap SH, Moshage H, Hazenberg B, Roelofs H, Bijzet J, Limburg P, et al. Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1991;1091(3):405-8.
  25. Dodds W, Iams J. Maternal C-reactive protein and preterm labor. The Journal of reproductive medicine. 1987;32(7):527-30.

Files

Share

How to cite

Statistics