Background:Considering the prevalence and effects of menopause on women's sexual performance and satisfaction and its relationship to the quality of marital life,this study aimed to investigate the effect of Aloe Vera vaginal cream on sexual performance and satisfaction in menopausal women.

Materials and Methods:The present study was a triple-blind,randomized,controlled clinical trial conducted on70postmenopausal women after obtaining consent and reviewing the inclusion criteria.Participants completed the FSFI and Hudson-Harrison Sexual Satisfaction Questionnaires and were randomly assigned to two groups:drug and placebo.

The intervention included the use of aloe vera vaginal cream and, in the control group,placebo(vaginal cream without any active pharmaceutical ingredient),every night for the first two weeks, and three nights a week for the next 6 weeks and during sexual intercourse,for 8 weeks.The questionnaires were completed again 4 and 8 weeks after the start of the intervention.Data analysis was performed using SPSS version 21 software and Chi-square, independent T-test, Kolmogorov-Smirnov, etc.

Results:Before the intervention, the two groups did not differ significantly in terms of demographic characteristics and baseline scores of sexual function and satisfaction. Four and eight weeks after the start of the intervention, the average sexual function, its domains, and sexual satisfaction in the intervention group were significantly higher than in the control group. While these changes were not significant in the control group.

Conclusion:Using aloe vera vaginal cream can significantly improve sexual function and satisfaction in menopausal women and can be used as a non-pharmacological, alternative, and complementary therapeutic approach.

Keywords:Aloe vera, vaginal cream, sexual function, sexual satisfaction, menopause