The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

DBD Plasma in Chronic Vaginitis

Document Type : Original Article

Authors
Soodabeh Darvish 1
Nastaran Teymoorianfard 2
Mina Bakhshali Bakhtiari 3
Ara Omranipour 3
1 Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Resident, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Gynecologist, National Association Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
10.22038/ijogi.2026.89194.6476
Abstract
Introduction: Given the high prevalence of chronic vaginitis, the importance of appropriate and effective treatment, along with the necessity to understand the efficacy and potential side effects of novel therapies in these patients, this study was conducted with aim to determine the effect of topical DBD plasma administration in chronic vaginitis.
Methods: In this cross-sectional analytical study, 50 women with chronic vaginitis referred to gynecology clinics at Shahid Beheshti University of Medical Sciences in Tehran in 2024 were selected based on inclusion criteria through convenience sampling. Using randomized blocks, they were assigned to two groups: intervention (n=25, standard treatment + 4 weeks of DBD plasma therapy) and control (n=25, standard treatment alone). The primary outcome (clinical symptom severity) and secondary outcomes (satisfaction rate and complications) were compared between the two groups. Data were analyzed using SPSS (version 23) and Paired t-tests, repeated-measures ANOVA, and chi-square tests. P<0.05 was considered significant.
Results: The most common reason for referral in both the intervention (60%) and control (68%) groups was recurrent vaginal infection, with no significant difference between the two groups (p=0.769). Post-intervention, vaginal infection severity was predominantly mild in the intervention group (68%) versus moderate in the control group (80%), with a statistically significant difference (p<0.001). Most patients receiving DBD plasma therapy (56%) reported complete satisfaction with the treatment. Only 2 subjects (8%) experienced plasma-related side effects, including mild burning and itching).
Conclusion: DBD plasma along with standard treatment reduces clinical symptom severity in chronic vaginitis and is associated with high satisfaction rates and minimal complications.
Keywords
Disease Outcome
Patient Satisfaction
Plasma
Vaginitis
Subjects
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The Iranian Journal of Obstetrics, Gynecology and Infertility
Volume 29, Issue 3
May 2026
Pages 10-18