The Iranian Journal of Obstetrics, Gynecology and Infertility

The Iranian Journal of Obstetrics, Gynecology and Infertility

Investigation and comparison of AMH in patients with tubular ectopic pregnancy treated with methotrexate and laparoscopy: A clinical trials study

Articles in Press

Document Type : Original Article

Authors
marzieh Aghahoseini 1
Ashraf Aleyasin 1
Atoosa Etezadi 2
marziye asadpour 3
Sahar Bagheri 3
marzieh ebrahimi 3
1 Associate Professor, Department of Obstetrics and Gynecology, Fellowship of Infertility, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2 Assistant professor of Infertility & IVF, Reproductive Health Research Center, Department of Obstetrics & Gynecology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
3 Department of Gynecology and Obstetrics, Infertility Unit, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
10.22038/ijogi.2026.83733.6248
Abstract
Introduction: we investigated the effects of existing treatments for EP (salpingectomy and MTX) on ovarian reserve by estimating AMH levels.

Methodology: After selecting the patients, the clinical condition of 50 patients was examined. After performing laboratory and specialized tests based on clinical conditions in two groups, group 1: 25 patients will undergo laparoscopy and group 2: 25 patients will be treated with methotrexate (as a single dose and 1 mg/g). . The level of AMH was evaluated before surgical or drug intervention and 3 to 6 months after discharge in all cases, and its level in primary and secondary measurements and its changes were compared between the two groups.

Results: Based on the main results of this study, there was no significant difference between the two groups in terms of changes in AMH levels. The reduction rate was slightly higher in the MTX group. Regarding the basic and secondary AMH level, the difference between the two groups was not significant. As a side finding, you can see that there was a significant inverse correlation between age and primary and secondary AMH levels in two groups of patients, and this correlation was stronger in the group of patients under MTX.

Conclusion: As a result of the present study, the current applications of single-dose MTX systemic and laparoscopic unilateral salpingectomy as common and safe treatment options for EP have no difference in terms of effect on ovarian reserve.
Keywords
ectopic pregnancy
salpingectomy
methotrexate
Ovarian reserve
Subjects
The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 08 July 2026