Effects of Vitamin D with and without Vitamin B6 in the Prevention of Carpal Tunnel Syndrome in Women Undergoing Breast Radiotherapy

Articles in Press

Document Type : Original Article

Authors

1 Assistant Professor of Orthopaedics, Department of Orthopedics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

2 استادیار ارتوپدی، ، گروه ارتوپدی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

3 دانشیار ارتوپدی، ، گروه ارتوپدی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران.

4 استادیار جراحی ستون فقرات، گروه ارتوپدی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران

10.22038/ijogi.2025.82516.6207

Abstract

Introduction: Research suggests that the combined intake of vitamin D and vitamin B6 can reduce inflammation and enhance nerve function. However, the extent and mechanism of their impact on patients undergoing breast radiotherapy have not been fully established. Further studies are needed to assess the role of this vitamin combination in preventing carpal tunnel syndrome (CTS) in these patients.

Materials and Methods: This randomized, double-blind clinical trial was conducted on women with breast cancer undergoing radiotherapy. A total of 120 patients, meeting inclusion and exclusion criteria, were divided into three groups: one receiving 200 IU of vitamin D daily, another receiving both 200 IU of vitamin D and 200 mg of vitamin B6 daily, and a control group. Patients were followed for three months and evaluated monthly for the development of CTS and pain intensity.

Results: The Phalen test, compression test, and pain intensity showed significantly better outcomes in the vitamin D±B6 group compared to the other two groups. Furthermore, patients receiving vitamin D±B6 exhibited only mild symptoms of CTS, while the control group experienced moderate symptoms after three months of radiotherapy.

Conclusion: This study demonstrated that the combined use of vitamin D and B6 significantly prevents the development of carpal tunnel syndrome in women undergoing breast radiotherapy.

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Main Subjects

The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 17 December 2025

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