Document Type : Review Article
Authors
1
PhD Student, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2
, Department of Nursing and Midwifery, MMS.C.,Islamic Azad University, Mashhad, Iran
3
Assistant Professor, Department of Community Medicine, Faculty Of Medicine , Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran
10.22038/ijogi.2025.87836.6430
Abstract
Introduction:
Oligostenoteratospermia (OAT) is one of the most common causes of male infertility that causes changes in sperm parameters. Increased production of oxygen free radicals (ROS) can lead to cell damage and reduced fertility. Inositol (MYO) can improve some of the sperm parameters such as their motility and progressive movement and reduce the negative effects of ROS. Therefore, this study was conducted to investigate the effectiveness of myoinositol-containing compounds on sperm parameters with oligoostenoteratospermia.
Methods: A systematic search was conducted in Magiran, PubMed, Scopus, Web of Science, Cochrane, SID, and Google Scholar databases using Persian keywords (infertility, inositol, male fertility, sperm motility) and English (infertility), inositol, male fertility, sperm motility) using Boolean operators AND and OR, and studies published up to 2024 were included in the study. Data analysis was performed using Egger software. Cochrane test and I^2 index were used to examine the homogeneity of studies. Results: Out of 23492 identified articles, 10 articles were included in the study, of which 4 articles were eligible for meta-analysis. The results showed that oral consumption of myo-inositol-containing compounds in infertile men (OAT) is associated with an increase in sperm parameters including motility, forward motility, and normal sperm concentration and morphology. Discussion: The findings indicate that the consumption of Myo-inositol can significantly improve sperm parameters and fertility in OAT men and can be used as an effective supplement in the treatment of OAT male infertility.
Keywords: infertility, inositol, male fertility, sperm motility
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