Comparison of pregnancy rate in double embryo transfer , mixed embryo transfer and blastocyst transfer in patients with a history of recurrent implantation failure

Articles in Press

Document Type : Original Article

Authors

1 iran university of medical science

2 iran university of mrdical science

3 Medicine, Iran University of Medical Sciences,

4 sharekord university

5 school of medical sciences, shahid beheshti university of medical science , tehran , Iran

10.22038/ijogi.2025.80975.6132

Abstract

Introduction: Repeated implantation failure is inability to achieve pregnancy despite the transfer of multiple high-quality embryos. Several investigations have shown a higher pregnancy rate with blastocyst ,double,or mixed transfers than cleavage stage embryo transfers. In this study, the pregnancy rates in these three transfer methods were compared in patients with repeated implantation failure.

Methods: The present study was conducted in a retrospective cross-sectional in patients with repeated impantation failure. All these cases had 3-day-old frozen embryos. After preparing the endometrium with the hormones, in one group, embryos were transferd blastocyst, and in another group, three-day-old embryos and then embryo-blastocyst (double transfer), and in the third group, three-day-old and 5-day-old embryos were also performed together. Chemical and clinical pregnancy were compared .

Results:, age, body mass index, infertility period, and endometrial size were not significantly different from each other. chemical pregnancy was in the blastocyst group (38.6%), the double group (29.8%) and the mix group (19.4%). Clinical pregnancy was in the blastocyst group (26.3%), followed by the double group (17.5%) and the mixed group (11.1%), despite the higher pregnancy in the blastocyst transfer, no significant statistical difference was.. There were two cases of miscarriage in the blastocyst transfer and one case of heterotopic pregnancy in the double group.

Conclusion. No statistically significant difference in chemical and clinical pregnancy ingroups, but the percentage of chemical and clinical pregnancy was higher in the blastocyst transfer group than the other two groups.

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The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 25 September 2025

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