Investigating the role of vaginal microbiota changes on reproductive health: a review study

Articles in Press

Document Type : Review Article

Authors

1 Isfahan - Isfahan University of Medical Sciences - Faculty of Nursing and Midwifery

2 Director of Midwifery and Reproductive Health Department, Isfahan Nursing and Midwifery Faculty, Isfahan Medical Sciences, Iran

10.22038/ijogi.2025.85742.6342

Abstract

Introduction: Infertility as a public health problem has many consequences on the mental, psychological and physical health of couples. Bacterial infections of the genitourinary tract play an important role in disrupting the vaginal microbiota, which is of great clinical importance as one of the causes of infertility. The purpose of this study is to investigate the role of vaginal microbiota changes on fertility health by reviewing the available literature.



Methodology: This review study by searching information databases including SID, Iranmedex, Irandoc and Magiran Cochrane, Science Direct, ISI Web of science PubMed, and Scopus and Google Scholar with keywords bacterial agent, bacterial vaginitis, vaginal microbiota, vaginal flora, reproductive health, women was done. The studies published in the period from 2000 to 2022 in English and Farsi were examined. The quality of the articles was evaluated using the consort (2017) checklist. Among 153 studies, 24 studies were selected.

Results: Vaginal bacterial agents lead to the occurrence of bacterial vaginosis, pelvic inflammatory disease and chronic endometritis through the reduction of lactobacilli and the increase of anaerobic bacteria, as well as through the activation of the cellular immune system and the production of inflammatory cytokines in infertility. have a role

Discussion and conclusion: Screening for vaginal bacterial infections in women suffering from female infertility and using therapeutic strategies to restore and regulate the vaginal microbiota can help in achieving more success in assisted reproductive treatments.

Keywords: bacteria, microbiota, vagina, reproductive health

Keywords

Main Subjects

The Iranian Journal of Obstetrics, Gynecology and Infertility

Articles in Press, Accepted Manuscript
Available Online from 08 June 2025

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